485403-18-7Relevant academic research and scientific papers
METHOD FOR PRODUCING FLUORINE-CONTAINING ALCOHOL
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Page/Page column 6, (2008/06/13)
PROBLEM TO BE SOLVED: To provide a method for the production of a fluorine-containing alcohol, preventing the formation of scale, suppressing side reactions, producing the alcohol in a short time in high yield and selectivity and suitable for mass-production. SOLUTION: A fluorine-containing alcohol expressed by general formula (2): Rf(A)OH (Rf is a 1-10C perfluoroalkyl group; and A is a 3-10C straight or branched-chain saturated hydrocarbon group) is produced by reacting a fluorine-containing alkyl halide expressed by general formula (1); Rf(A)X (X is a halogen atom) with an alkali metal 4-hydroxybutyrate using γ-butyrolactone as a solvent while keeping the reaction temperature to 90-130°C.
PROCESS FOR PRODUCING FLUORINATED ALCOHOL
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Page 4, (2010/02/06)
A method for producing fluorinated alcohols from fluorinated alkyl halides can produce fluorinated alcohols at high product yield and at high selectivity in a single-step reaction. The method eliminates the need to use heavy metals and other toxic compounds that are difficult to handle or process. Specifically, the method produces a fluorinated alcohol represented by the following general formula (2):Rf(A)OH wherein Rf represents a perfluoroalkyl group having 1 to 10 carbon atoms; and A represents a straight-chained or branched saturated hydrocarbon group having 3 to 10 carbon atoms. The method is characterized in that it allows a fluorinated alkyl halide represented by the following general formula (1) to react with an alkali metal salt of 4-hydroxybutyrate in a gamma-butyrolactone solvent:Rf(A)X wherein Rf and A are as defined above; and X represents a halogen atom.
