57769-01-4Relevant articles and documents
Kinetic and mechanistic studies on the oxidation of pyrrolidine by bis(hydrogenperiodato)argentate(III) complex anion
Zhang, Jiong,Huo, Shuying,Shi, Hongmei,Shen, Shigang,Shang, Yanli
, p. 15 - 20 (2013)
The kinetics of oxidation of pyrrolidine by bis(hydrogenperiodato) argentate(III) complex anion ([Ag(HIO6)2]5-) was studied in alkaline medium, with reaction temperatures in the range of 15.0-30.0 C. The experiments indicated that the oxidation follows an overall second-order reaction, being first-order in both Ag(III) and pyrrolidine. The observed second-order rate constants, k′, decreased with increasing [IO4 -] but increased slightly with increasing [OH -]. The influence of ionic strength on the reaction rate was also investigated. The oxidation resulted in oxidative deamination of pyrrolidine, giving 4-hydroxybutyrate as the product. A reaction mechanism is proposed which includes an equilibrium between [Ag(HIO6)2]5- and [Ag(HIO6)2(OH)(H2O)]2-; these two Ag(III) species are reduced by pyrrolidine in parallel rate-determining steps. The rate equation derived from the proposed mechanism can explain the experimental observations. The rate constants of the rate-determining steps, together with the associated activation parameters, were calculated accordingly.
GAMMA-HYDROXYBUTYRATE COMPOSITIONS AND THEIR USE FOR THE TREATMENT OF DISORDERS
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Paragraph 00222, (2018/10/19)
Provided herein are pharmaceutical compositions and formulations comprising mixed salts of gamma-hydroxybutyrate (GHB). Also provided herein are methods of making the pharmaceutical compositions and formulations, and methods of their use for the treatment of sleep disorders such as apnea, sleep time disturbances, narcolepsy, cataplexy, sleep paralysis, hypnagogic hallucination, sleep arousal, insomnia, and nocturnal myoclonus.
NEW PROCESS FOR THE PREPARATION OF NITROOXYDERIVATIVES OF PARACETAMOL
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Page/Page column 6; 7, (2010/02/11)
The present invention relates to a new process for the preparation of a compound of the following formula (I).