4855-08-7

Upstream product

• 4147-00-6 4-tert-butyl-1-(1-pyrrolidinyl)cyclohexene 
• 100-39-0 benzyl bromide 
• 88044-20-6 (2S,4R)-4-tert-Butyl-2-(hydroxy-phenyl-methyl)-cyclohexanone 
• 100-52-7 benzaldehyde 
• 88044-20-6 (2S,4S)-4-tert-Butyl-2-(hydroxy-phenyl-methyl)-cyclohexanone 
• 19980-19-9 4-t-butyl-1-trimethylsilyloxy-1-cyclohexene 
• 98-53-3 4-tercbutyl-cyclohexanone 

Relevant academic research and scientific papers

Application of piperazine-derived hydrazone linkers for alkylation of solid-phase immobilized ketones

The preparation and application of three new solid supports with piperazine-derived hydrazine anchoring groups are described. The supports were used for immobilization of ketones. The ketones: cyclohexanone, 4-tert-butylcyclohexanone, 3-pentanone and tropinone, which were bound to polymers in the form of their hydrazones, were deprotonated with LDA and alkylated with propyl iodide or benzyl bromide. The resulting alkylated products were cleaved off the solid support on treatment with trifluoroacetic acid in dichloromethane. Linkers with 6- and 3-carbon atom spacers gave better results than the simple N-aminopiperazine linker.

ALDOL REACTION OF TRICHLOROTITANIUM ENOLATES. REVALUATION OF THE BOAT TRANSITION STATE

The trichlorotitanium enolates generally undergo an erythro selective aldol reaction except one case which gives a threo aldol.A new form of the boat transition state has been proposed.