486437-13-2Relevant academic research and scientific papers
Some mechanistic aspects of a nickel-catalyzed electrochemical cross-coupling between aryl halides and substituted chloropyridazines
Urgin, Karène,Barhdadi, Rachid,Condon, Sylvie,Léonel, Eric,Pipelier, Muriel,Blot, Virginie,Thobie-Gautier, Christine,Dubreuil, Didier
, p. 4495 - 4500 (2010)
The nickel-2,2′-bipyridine catalyzed electrochemical cross-coupling reaction between an aryl halide and a chloropyridazine was investigated by an electrochemical study. The electrochemical behavior of the divalent nickel complex is affected by the presenc
Preparation of functionalized aryl- and heteroarylpyridazines by nickel-catalyzed electrochemical cross-coupling reactions
Sengmany, Stephane,Leonel, Eric,Polissaint, Frantz,Nedelec, Jean-Yves,Pipelier, Muriel,Thobie-Gautier, Christine,Dubreuil, Didier
, p. 5631 - 5636 (2008/02/09)
(Chemical Equation Presented) A general efficient electrochemical method for the preparation of aryl- and heteroarylpyridazines in a nickel-catalyzed cross-coupling reaction of 3-chloro-6-methoxypyridazine and 3-chloro-6- methylpyridazine with a range of functionalized aryl or heteroaryl halides is reported.
Heteroarylcarboxylic acid amides, the preparation thereof and their use as pharmaceutical compositions
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, (2008/06/13)
A compound of formula wherein: Aa, Ra, X1 to X4, Het, and R5 to R7 are defined as in claim 1, the isomers and the salts thereof, particularly the physiologically acceptable salts thereof, which are valuable inhibitors of the microsomal triglyceride-transfer protein (MTP), medicaments containing these compounds and their use, as well as the preparation thereof.
Combination of MTP inhibitors or apoB-secretion inhibitors with fibrates for use as pharmaceuticals
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, (2008/06/13)
The invention relates to the use of fibrates for lowering the liver toxicity of MTP inhibitors as well as pharmaceutical compositions containing an MTP inhibitor and a fibrate.
