487027-06-5

Upstream product

• 3111-51-1 2,4-dibromo-5-hydroxybenzaldehyde 
• 100-83-4 meta-hydroxybenzaldehyde 
• 75-52-5 nitromethane 
• 99615-74-4 2,4-dibromo-5-methoxylbenzaldehyde 

Downstream Products

• 487027-08-7 2-(2,4-dibromo-5-methoxyphenyl)-2-(thiophenyl)-1-nitroethane 
• 499781-35-0 3-tert-butyl-7a-[1-(2,4-dibromo-5-methoxy-phenyl)-2-nitro-ethyl]-2-methyl-hexahydro-pyrrolo[1,2-c]imidazol-1-one 
• 487027-10-1 (2S)-N-[2-(2,4-dibromo-5-methoxyphenyl)-2-(thiophenyl)ethyl]-1-methyl-2-pyrrolidinecarboxamide 
• 487027-09-8 2-(2,4-dibromo-5-methoxyphenyl)-2-(thiophenyl)-1-aminoethane 
• 499781-40-7 (5S,8S,9R)-8-hydroxy-9-(4,6-dibromo-3-methoxyphenyl)-7-methyl-1-(2,2,2-trifluoroacetyl)-1,7-diaza-6-oxospiro[4,4]nonane 

Relevant academic research and scientific papers

Asymmetric synthesis of amathamides A and B: Novel alkaloids isolated from Amathia wilsoni

Syntheses of the amathamides A and B ((2S)-N-[(E and Z)-2(2,4-dibromo-5-methoxyphenylethenyl]-1-methyl-2-pyrrolinecarboxamides), new alkaloids isolated from the Tasmanian marine bryozoan Amathia wilsoni, were accomplished by a sequence of reactions starting from 3-hydroxybenzaldehyde.

The total synthesis of (-)-amathaspiramide F

Breaking the cis rule: L-Proline and not as expected D-proline led to (-)-amathaspiramide F with the correct configuration in a short sequence of steps (see retrosynthetic scheme). This synthesis features an exception to the principle of self-regeneration

Total synthesis of newbouldine via reductive N-N bond formation

The first total synthesis of newbouldine has been achieved employing a new, reductive N-N bond forming reaction. The asymmetric synthesis confirms that the natural product is a racemate.