487047-93-8

Upstream product

• 104015-38-5 tert-butyl 2-benzoylpropionate 

Downstream Products

• 487047-97-2 (2R,3R)-methyl 2-fluoro-3-hydroxy-2-methyl-3-phenylpropanoate 
• 487047-96-1 (2R,3S)-methyl 2-fluoro-3-hydroxy-2-methyl-3-phenylpropanoate 
• 487048-00-0 (2R,3S)-3-Azido-2-fluoro-2-methyl-3-phenyl-propionic acid methyl ester 
• 487047-98-3 (2R,3R)-3-Azido-2-fluoro-2-methyl-3-phenyl-propionic acid methyl ester 
• 144462-33-9 (R)-methyl 2-fluoro-2-methyl-3-oxo-3-phenyl-propionate 

Relevant academic research and scientific papers

Enantioselective Fluorination of α-Branched β-Ynone Esters Using a Cinchona-Based Phase-Transfer Catalyst

Herein, we report the fluorination of α-branched β-ynone esters to afford their corresponding quaternary fluorinated products with good enantioselectivity (ee = 73-90%) using a cinchona-based phase-transfer catalyst. α-Branched β-ynone esters possess a highly acidic α-proton and form their corresponding enolate as a single isomer, which allows the enantioselective fluorination reaction to occur under standard cinchona-based phase-transfer catalyst conditions. Moreover, the obtained α-fluorinated product can be treated with [(SPhos)AuNTf2] (1 mol %) to afford a fluorinated 3,5-diketo carboxylic acid.

Immobilization and reuse of Pd complexes in ionic liquid: Efficient catalytic asymmetric fluorination and Michael reactions with β-ketoesters

(Matrix presented) Palladium complexes (1 and 2) were immobilized in ionic liquids, and their applications to catalytic asymmetric fluorination and Michael reaction of β-ketoesters were successfully demonstrated. This immobilization enabled the reuse of t

DIPHOSPHINE LIGAND AND TRANSITION METAL COMPLEX USING THE SAME

The present invention provides a novel ligand represented by the following formula and a novel transition metal complex having the ligand, which shows superior enantioselectivity and catalytic efficiency, particularly high catalyst activity, in various asymmetric synthesis reactions. A transition metal complex having, as a ligand, a compound represented by the formula wherein R4 is a hydrogen atom or a C1-6 alkyl group optionally having substituent(s), and R5 and R6 are each a C1-6 alkyl group optionally having substituent(s), or the formula is a group represented by the formula wherein ring B is a 3- to 8-membered ring optionally having substituent (s).

Asymmetric fluorination of β-keto esters catalyzed by chiral rare earth perfluorinated organophosphates

Novel chiral rare earth metal complexes bearing perfluorinated binaphthyl phosphate ligand RE[(R)-F8BNP]3 (RE = rare earth; F8BNP = 5,5′,6,6′,7,7′,8,8′-octafluoro-1,1′-binaph thyl-2,2′-diyl phosphate) have been synthesized

Highly enantioselective fluorination reactions of β-ketoesters and β-ketophosphonates catalyzed by chiral palladium complexes

Using chiral palladium enolates as key intermediates, efficient catalytic enantioselective fluorination reactions of active methine compounds have been developed. These reactions can be conducted in alcoholic solvents without any precaution to exclude wat

An efficient enantioselective fluorination of various β-ketoesters catalyzed by chiral palladium complexes

Reflecting the importance of fluorinated organic compounds in medicinal chemistry, development of an efficient method for catalytic enantioselective fluorination is increasingly desirable. Using a novel palladium complex 2 (1-2.5 mol %), various β-ketoest