144462-33-9

Basic information

• Product Name: Benzenepropanoic acid, alpha-fluoro-alpha-methyl-beta-oxo-, methyl ester, (R)- (9CI)
• Synonyms: Benzenepropanoic acid, alpha-fluoro-alpha-methyl-beta-oxo-, methyl ester, (R)- (9CI)
• CAS NO: 144462-33-9
• Molecular Formula: C₁₁H₁₁FO₃
• Molecular Weight: 210.2016432
• Product Categories: ACETYLHALIDE
• Mol File: 144462-33-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 272.1±20.0 °C(Predicted)
• Appearance: /
• Density: 1.171±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Benzenepropanoic acid, alpha-fluoro-alpha-methyl-beta-oxo-, methyl ester, (R)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoic acid, alpha-fluoro-alpha-methyl-beta-oxo-, methyl ester, (R)- (9CI)(144462-33-9)
• EPA Substance Registry System: Benzenepropanoic acid, alpha-fluoro-alpha-methyl-beta-oxo-, methyl ester, (R)- (9CI)(144462-33-9)

Safety Data

• Hazardous Substances Data: 144462-33-9(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 67-56-1 methanol 
• 1027604-85-8 (3S,4S,6R,7S,10R)-3,4-Difluoro-7-isopropyl-3,10-dimethyl-4-phenyl-1,5-dioxa-spiro[5.5]undecan-2-one 
• 32742-19-1 methyl 2-benzoylpropionate 
• 104015-38-5 tert-butyl 2-benzoylpropionate 
• 487047-93-8 (R)-tert-butyl 2-fluoro-2-methyl-3-oxo-3-phenyl-propionate 
• 4767-01-5 2-methyl-3-oxo-3-phenylpropionic acid 
• 87769-43-5 2,2,5-Trimethyl-6-phenyl-[1,3]dioxin-4-one 
• 144462-27-1 (6S,7S,10R)-7-Isopropyl-3,10-dimethyl-4-phenyl-1,5-dioxa-spiro[5.5]undec-3-en-2-one 

Downstream Products

• 487048-00-0 (2R,3S)-3-Azido-2-fluoro-2-methyl-3-phenyl-propionic acid methyl ester 
• 487047-98-3 (2R,3R)-3-Azido-2-fluoro-2-methyl-3-phenyl-propionic acid methyl ester 
• 487047-97-2 (2R,3R)-methyl 2-fluoro-3-hydroxy-2-methyl-3-phenylpropanoate 
• 487047-96-1 (2R,3S)-methyl 2-fluoro-3-hydroxy-2-methyl-3-phenylpropanoate 
• 106815-12-7 (R)-ethyl 2-methyl-2-fluoro-3-oxo-3-phenylpropanoate 

Relevant articles and documents

Highly enantioselective fluorination reactions of β-ketoesters and β-ketophosphonates catalyzed by chiral palladium complexes

Using chiral palladium enolates as key intermediates, efficient catalytic enantioselective fluorination reactions of active methine compounds have been developed. These reactions can be conducted in alcoholic solvents without any precaution to exclude wat

An efficient enantioselective fluorination of various β-ketoesters catalyzed by chiral palladium complexes

Reflecting the importance of fluorinated organic compounds in medicinal chemistry, development of an efficient method for catalytic enantioselective fluorination is increasingly desirable. Using a novel palladium complex 2 (1-2.5 mol %), various β-ketoest