3423-37-8

Basic information

• Product Name: Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-1-(phenylmethyl)-
• CAS NO: 3423-37-8
• Molecular Formula: C18H21NO2
• Molecular Weight: 283.37
• Mol File: 3423-37-8.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-1-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-1-(phenylmethyl)-(3423-37-8)
• EPA Substance Registry System: Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-1-(phenylmethyl)-(3423-37-8)

Safety Data

• Hazardous Substances Data: 3423-37-8(Hazardous Substances Data)

Upstream product

• 101-97-3 Ethyl 2-phenylethanoate 
• 4876-02-2 N-(3,4-dimethoxyphenethyl)-phenyl acetamide 
• 20359-09-5 (6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)(phenyl)methanone 
• 122-78-1 phenylacetaldehyde 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 103-82-2 phenylacetic acid 
• 4876-00-0 1-benzyl-6,7-dimethoxy-3,4-dihydro-isoquinoline 
• 20226-04-4 1-benzyl-6,7-dimethoxy-3,4-dihydroisoquinoline-hydrochloride 
• 103-80-0 phenylacetyl chloride 

Downstream Products

• 114873-36-8 1-Benzyl-2-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline; hydrochloride 
• 120034-55-1 (1S)-1,2,3,4-tetrahydro-1-benzoyl-6,7-dimethoxy-2-<((R)-1-phenylethyl)carbamoyl>isoquinoline 
• 120034-56-2 (1R)-1,2,3,4-tetrahydro-1-benzoyl-6,7-dimethoxy-2-<((R)-1-phenylethyl)carbamoyl>isoquinoline 
• 91-01-0 1,1-Diphenylmethanol 
• 464-72-2 tetraphenylethane-1,2-diol 
• 23818-73-7 6,7-dimethoxy-1-benzylisoquinoline 
• 3423-13-0 1-benzyl-6,7-dimethoxy-N-methyl-1,2,3,4-tetrahydroisoquinoline 
• 14347-96-7 6,7-Dimethoxy-2-ethyl-1-benzyl-1,2,3,4-tetrahydroisochinolin 
• 1007356-48-0 C₂₆H₂₉NO₂ 
• 20359-09-5 (6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)(phenyl)methanone 
• 1147272-79-4 N-phenoxyethyl-6,7-dimethoxy-1-benzyl-1,2,3,4-tetrahydroisoquinoline 
• 876066-63-6 1-benzyl-5,8-dichloro-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride 
• 14919-82-5 6,7DHBnTIQ 
• 47145-36-8 (1S)-1-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

Enhancement of the carbamate activation rate enabled syntheses of tetracyclic benzolactams: 8-oxoberbines and their 5- And 7-membered C-ring homologues

A route to the direct amidation of aromatic-ring-tetheredN-carbamoyl tetrahydroisoquinoline substrates was developed. This route enabled general access to 8-oxoberberines and their 5- and 7- membered C-ring homologues. It overcomes the undesired tandem side-reactions that result in the destruction of the isoquinoline backbone, which inevitably occurred under our previously reported superacidic carbamate activation method.

Synthesis of 8-oxoberbines and related benzolactams by Pd(OAc) 2-catalyzed direct aromatic carbonylation

A variety of alkoxy-substituted benzolactams with a berbine or yohimbane skeleton were prepared from 1-benzyl-1,2,3,4-tetrahydroisoquinolines or 1-benzyl-1,2,3,4-tetrahydro-β-carbolines by a phosphine-free Pd(II)-catalyzed direct aromatic carbonylation in a Pd(OAc)2-Cu(OAc) 2 catalytic system. The site selectivity was compared with that of the carbonylation with Pd(OAc)2 or Pd(OAc)2·2 PPh3, respectively.

O-Benzenedisulfonimide as a reusable acid catalyst for an easy, efficient, and green synthesis of tetrahydroisoquinolines and tetrahydro-β-carbolines through Pictet-Spengler reaction

The synthesis of tetrahydroisoquinolines and tetrahydro-β-carbolines, using the Pictet-Spengler reaction, was carried out in the presence of a catalytic amount of o-benzenedisulfonimide, which worked as a Br?nsted acid organocatalyst. The reaction conditi