488721-34-2

Upstream product

• 488721-33-1 Benzoic acid (E)-(1R,6S)-1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-7-hydroxy-6-methyl-hept-2-enyl ester 
• 98-88-4 benzoyl chloride 
• 488721-32-0 Benzoic acid (E)-(1R,6S)-1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-6-methyl-7-triisopropylsilanyloxy-hept-2-enyl ester 
• 488721-31-9 (1R,6S)-1-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-6-methyl-7-triisopropylsilanyloxy-hept-2-yn-1-ol 

Downstream Products

• 488721-35-3 Benzoic acid (E)-(1R,6S,7R)-10-[(2S,4R,6R)-4-(tert-butyl-dimethyl-silanyloxy)-6-ethoxycarbonylmethyl-tetrahydro-pyran-2-yl]-1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-7-hydroxy-6-methyl-9-oxo-dec-2-enyl ester 
• 488721-36-4 Benzoic acid (E)-(1R,6S,7R,9R)-10-[(2R,4R,6R)-4-(tert-butyl-dimethyl-silanyloxy)-6-ethoxycarbonylmethyl-tetrahydro-pyran-2-yl]-1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-7,9-dihydroxy-6-methyl-dec-2-enyl ester 
• 488721-38-6 [4-(tert-butyl-dimethyl-silanyloxy)-6-(3-{6-[2-(2,2-dimethyl-[1,3]dioxolan-4-yl)-2-hydroxy-1-(2,4,6-triisopropyl-phenylselanyl)-ethyl]-3-methyl-tetrahydro-pyran-2-yl}-2-hydroxy-propyl)-tetrahydro-pyran-2-yl]-acetic acid methyl ester 

Relevant academic research and scientific papers

Leucascandrolide A: Synthesis and Related Studies

The total synthesis of the biologically active marine natural product leucascandrolide A is reported. A convergent strategy is employed, allowing for the rapid assembly of the macrolide moiety. Key steps of our approach include the diastereoselective addi

Total synthesis of leucascandrolide A

A compound that could never be isolated again despite intensive efforts after it was first found in the sponge Leucascandra caveolata in 1996 is leucascandrolide A (1). An enantioselective, convergent total synthesis of this polyoxygenated marine macrolid