488791-43-1Relevant articles and documents
Conformation-activity relationships in polyketide natural products. Towards the biologically active conformation of epothilone
Taylor, Richard E.,Chen, Yue,Galvin, Gabriel M.,Pabba, Praveen K.
, p. 127 - 132 (2007/10/03)
The conformation-activity relationships for the biologically active polyketide, epothilone, have been determined. Computer-based molecular modeling and high field NMR techniques have provided the solution preferences for epothilones 1 and 2. For the C1-C8
Conformation-activity relationships in polyketide natural products: A new perspective on the rational design of epothilone analogues
Taylor, Richard E.,Chen, Yue,Beatty, Alicia,Myles, David C.,Zhou, Yiqing
, p. 26 - 27 (2007/10/03)
The syntheses of C14-methyl analogues of epothilone B and D are described. Conformational analysis using computational methods, X-ray crystallography, and NMR studies showed that the stereochemistry at C14 has a pronounced effect on the conformation of th