488791-49-7

Upstream product

• 488791-33-9 (E)-(3S,4R)-2,4-Dimethyl-1-(2-methyl-thiazol-4-yl)-hexa-1,5-dien-3-ol 
• 488791-31-7 (E)-(2S,3S)-3-(tert-Butoxy-diphenyl-silanyloxy)-2,4-dimethyl-5-(2-methyl-thiazol-4-yl)-pent-4-enal 
• 184246-38-6 (E)-2-methyl-3-(2-methylthiazol-4-yl)acrylaldehyde 
• 488791-39-5 (S)-4-Benzyl-3-[(6E,10E)-(2S,8S,9S)-9-(tert-butoxy-diphenyl-silanyloxy)-6-chloromethyl-2,8,10-trimethyl-11-(2-methyl-thiazol-4-yl)-undeca-6,10-dienoyl]-oxazolidin-2-one 
• 488791-37-3 (S)-4-Benzyl-3-[(E)-(2S,8S,9S)-9-(tert-butoxy-diphenyl-silanyloxy)-7-hydroxy-2,8,10-trimethyl-6-methylene-11-(2-methyl-thiazol-4-yl)-undec-10-enoyl]-oxazolidin-2-one 
• 488791-34-0 4-[(E)-(3S,4R)-3-(tert-Butoxy-diphenyl-silanyloxy)-2,4-dimethyl-hexa-1,5-dienyl]-2-methyl-thiazole 
• 488791-45-3 (12Z,16E)-(3S,6R,7S,8S,14S,15S)-15-(tert-Butoxy-diphenyl-silanyloxy)-1,3-bis-(tert-butyl-dimethyl-silanyloxy)-7-hydroxy-4,4,6,8,12,14,16-heptamethyl-17-(2-methyl-thiazol-4-yl)-heptadeca-12,16-dien-5-one 
• 488791-41-9 (6Z,10E)-(2S,8S,9S)-9-(tert-Butoxy-diphenyl-silanyloxy)-2,6,8,10-tetramethyl-11-(2-methyl-thiazol-4-yl)-undeca-6,10-dien-1-ol 
• 488791-43-1 (6Z,10E)-(2S,8S,9S)-9-(tert-Butoxy-diphenyl-silanyloxy)-2,6,8,10-tetramethyl-11-(2-methyl-thiazol-4-yl)-undeca-6,10-dienal 
• 355009-17-5 3,5-bis-(tert-butyl-dimethyl-silanyloxy)-2,2-dimethyl-pentanoic acid phenyl ester 
• 355009-03-9 5-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-2,2-dimethyl-pentanoic acid phenyl ester 
• 187527-25-9 (-)-(5S)-5,7-bis{[tert-butyl(dimethyl)silyl]oxy}-4,4-dimethylheptan-3-one 
• 488791-47-5 (12Z,16E)-(3S,6R,7S,8S,14S,15S)-15-(tert-Butoxy-diphenyl-silanyloxy)-1,3,7-tris-(tert-butyl-dimethyl-silanyloxy)-4,4,6,8,12,14,16-heptamethyl-17-(2-methyl-thiazol-4-yl)-heptadeca-12,16-dien-5-one 

Relevant academic research and scientific papers

Conformation-activity relationships in polyketide natural products. Towards the biologically active conformation of epothilone

The conformation-activity relationships for the biologically active polyketide, epothilone, have been determined. Computer-based molecular modeling and high field NMR techniques have provided the solution preferences for epothilones 1 and 2. For the C1-C8

Conformation-activity relationships in polyketide natural products: A new perspective on the rational design of epothilone analogues

The syntheses of C14-methyl analogues of epothilone B and D are described. Conformational analysis using computational methods, X-ray crystallography, and NMR studies showed that the stereochemistry at C14 has a pronounced effect on the conformation of th