4892-03-9Relevant articles and documents
Methods for Treating Cognitive Disorders Using Inhibitors of Histone Deacetylase
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Paragraph 0644, (2017/01/23)
This disclosure relates to compounds for the inhibition of histone deacetylase and treatment of a cognitive disorder or deficit. More particularly, the disclosure provides for compounds of formula (I) wherein Q, J, L and Z are as defined in the specification.
Preparation 10H-dibenz [b, f] [1,4] parathiazine -11-ketone and method of quetiapine
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Paragraph 0042; 0043, (2017/03/08)
The invention provides a method for synthesizing a quetiapine mother-ring intermediate, and the method comprises the following steps: esterification of 2-nitro - 2'-carboxyl diphenyl sulfide, and under the right conditions, nitroreduction simultaneously with ester aminolysis to obtain the product 10 H-dibenzo[b,f][1,4]thiazepin-11-one and quetiapine by a one pot method. Compared with a traditional method, the method has the advantages of being simple in operation, high in yield, more suitable for industrial production, and the like.
IRON CATALYZED CROSS-COUPLING REACTIONS OF IMIDOYL DERIVATIVES
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Page/Page column 19; 48; 49, (2010/11/27)
Disclosed is a process for preparing a compound of formula A - N=C(D)(B), from a compound of formula A-N=C(E)(B) and a compound of formula D-M using an iron catalyst, where the process has is represented by Equation (I).