4892-03-9

Upstream product

• 88-73-3 2-Chloronitrobenzene 
• 4892-02-8 Methyl thiosalicylate 
• 147-93-3 Thiosalicylic acid 
• 1493-27-2 ortho-nitrofluorobenzene 
• 74-88-4 methyl iodide 
• 577-19-5 2-nitrophenyl bromide 
• 67-56-1 methanol 
• 19806-43-0 2?(2?nitrophenylsulfanyl)benzoic acid 

Downstream Products

• 3159-07-7 dibenzo[b,f][1,4]thiazepin-11-one 
• 6768-42-9 [3-(11H-dibenzo[b,f][1,4]thiazepin-10-yl)-propyl]-dimethyl-amine 
• 7196-53-4 2,2'-Bis-<2-methoxycarbonyl-phenylmercapto>-azoxybenzol 
• 97141-88-3 methyl 2-(2-nitrophenylsulphinyl)benzoate 
• 100866-62-4 2-(2-nitrophenylthio)benzoic acid methyl ester 

Relevant academic research and scientific papers

Methods for Treating Cognitive Disorders Using Inhibitors of Histone Deacetylase

This disclosure relates to compounds for the inhibition of histone deacetylase and treatment of a cognitive disorder or deficit. More particularly, the disclosure provides for compounds of formula (I) wherein Q, J, L and Z are as defined in the specification.

A process for the preparation of intermediates quetiapine (by machine translation)

The invention discloses a preparation method for a quetiapine intermediate. The preparation method comprises: taking thiosalicylic acid as an initial raw material to prepare 2-nitro-2'-carboxyldiphenyl sulfide, esterifying and reducing, and then performing intramolecular amino-ester exchange reaction for cyclization, so as to obtain the quetiapine intermediate 10,11-dihydro-11-oxodibenzo[b,f][1,4]thiazepine. The preparation method is simple, the target product is high in purity, the reaction yield is relatively high, the production cost is effectively reduced, and industrialized production of the high-purity quetiapine intermediate is facilitated to be realized.

Preparation 10H-dibenz [b, f] [1,4] parathiazine -11-ketone and method of quetiapine

The invention provides a method for synthesizing a quetiapine mother-ring intermediate, and the method comprises the following steps: esterification of 2-nitro - 2'-carboxyl diphenyl sulfide, and under the right conditions, nitroreduction simultaneously with ester aminolysis to obtain the product 10 H-dibenzo[b,f][1,4]thiazepin-11-one and quetiapine by a one pot method. Compared with a traditional method, the method has the advantages of being simple in operation, high in yield, more suitable for industrial production, and the like.

Syntheses of the tricyclic cores of clozapine, dibenzo[b,f][1,4]thiazepin- 11(10H)-one, and dibenzo[b,f][1,4]oxazepin-11(10H)-one in C-14 labeled form by [14C]carbonylation

Clozapine has been demonstrated to bind covalently to proteins as a result of metabolic activation that has been proposed to be a precursor to the serious side effects including death that occur in a small percentage of the population. The covalent modifi

IRON CATALYZED CROSS-COUPLING REACTIONS OF IMIDOYL DERIVATIVES

Disclosed is a process for preparing a compound of formula A - N=C(D)(B), from a compound of formula A-N=C(E)(B) and a compound of formula D-M using an iron catalyst, where the process has is represented by Equation (I).