490035-94-4

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 52562-19-3 2-isopropenylaniline 

Downstream Products

• 98598-96-0 tert-butyl 2-methyl-1H-indole-1-carboxylate 
• 21440-96-0 1,4-Dihydro-4,4-dimethyl-1,3-benzo[d]oxazin-2-one 
• 491-35-0 C₆H₄NCH₂CHCCH₂ 
• 402822-96-2 N-allyl-N-(t-butoxycarbonyl)-2-isopropenylaniline 

Relevant academic research and scientific papers

Catalytic Asymmetric Chlorocyclization of 2-Vinylphenylcarbamates for Synthesis of 1,4-Dihydro-2H-3,1-benzoxazin-2-one Derivatives

A facile synthetic approach to a series of chiral 4-chloromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one derivatives has been described. This transformation is achieved through the catalytic asymmetric chlorocyclization of 2-vinylphenylcarbamates using a newly developed organocatalyst. Furthermore, the resulting products can be easily converted into diverse bioactive agents.

Convenient synthesis of 1,4-dihydro-2H-3,1-benzoxazin-2-ones by iodocyclization of t-butyl 2-vinylphenylcarbamates

It has been found that t-butyl 2-vinylphenylcarbamate derivatives underwent iodocyclization on treatment with iodine in the presence of sodium hydrogencarbonate to afford 4-iodomethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one derivatives in generally good yields. The reduction of these 4-iodomethyl derivatives with tributyltin hydride gave the corresponding 4-methyl derivatives in good yields.

A novel synthesis of substituted quinolines using ring-closing metathesis (RCM): Its application to the synthesis of key intermediates for anti-malarial agents

A method for synthesizing substituted quinolines using ruthenium-catalyzed ring-closing metathesis as a key step has been developed. Substituted 1,2-dihydroquinolines, 4-silyloxy-1,2-dihydroquinoline and 4-methoxy-1,2- dihydroquinoline, were successfully synthesized in excellent yields via ene-ene metathesis and silyl or alkyl enol ether-ene metathesis, respectively. The synthetic intermediates of the antimalarial agents quinine, chloroquine, and PPMP-quinine hybrid were efficiently synthesized by this methodology.