98598-96-0

Basic information

• Product Name: tert-butyl 2-methyl-1H-indole-1-carboxylate
• Synonyms: tert-butyl 2-methyl-1H-indole-1-carboxylate
• CAS NO: 98598-96-0
• Molecular Formula: C₁₄H₁₇NO₂
• Molecular Weight: 231
• Mol File: 98598-96-0.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-butyl 2-methyl-1H-indole-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-methyl-1H-indole-1-carboxylate(98598-96-0)
• EPA Substance Registry System: tert-butyl 2-methyl-1H-indole-1-carboxylate(98598-96-0)

Safety Data

• Hazardous Substances Data: 98598-96-0(Hazardous Substances Data)

Upstream product

• 95-20-5 2-methyl-1H-indole 
• 6627-89-0 tert-butyl phenyl carbonate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 490035-94-4 tert-butyl N-[2-(1-methylethenyl)phenyl]carbamate 
• 74965-31-4 N-(tert-butoxycarbonyl)-o-toluidine 
• 552-89-6 2-nitro-benzaldehyde 
• 496043-66-4 2-[2'-(N-Boc-amino)-5'-chlorophenyl]-1,3-dithiane 
• 396094-78-3 2-[2'-(N-Boc-amino)phenyl]-1,3-dithiane 
• 111253-51-1 1-chloro-3-<(1,3-dithian)-2'-yl>-4-nitrobenzene 
• 35531-58-9 2-(2-nitrophenyl)-1,3-dithiane 
• 6628-86-0 5-chloro-2-nitrobenzaldehyde 
• 53165-23-4 2-(2'-amino-5'-chlorophenyl)-1,3-dithiane 
• 53165-22-3 2-(2'-aminophenyl)-1,3-dithiane 
• 496043-89-1 2-[2'-(N-Boc-N-trimethylsilyl-amino)-5'-chlorophenyl]-1,3-dithiane 

Relevant articles and documents

Enantioselective Construction of Dihydropyrido[1,2- a]indoles via Organocatalytic Arylmethylation of 2-Enals with Inert Aryl Methane Nucleophiles

An organocatalytic asymmetric arylmethylation/N-hemiacetalization of 2-indolyl methane derivatives and 2-enals was developed. Notably, the 2-methyl of indole was readily deprotonated to produce highly reactive nucleophilic species by introducing the nitro

Fluorine as a Traceless Directing Group for the Regiodivergent Synthesis of Indoles and Tryptophans

Despite ample evidence for the unique reactivity offered by hypervalent F-iodanes, mechanistic investigations fall far behind. In order to shed light on the unusual behavior of such F-reagents, we conducted computational and experimental studies on the chemodivergent transformation of styrenes. We identified the spirocyclic F-cyclopropane as the common intermediate for both the C,H-fluorination and C,H-amination pathways. The fate of this key compound is determined by the extent of cationic charge delocalization controlled by the N-substituents. Exploiting this phenomenon, a multitude of different transformations have become available, leading, i.e., to the regiodivergent synthesis of indoles and tryptophans.

Palladium-catalyzed diastereoselective oxyarylation of 2-alkylindoles

Diastereoselective oxyarylation of N-protected 2-alkylindoles with commercially available boronic acids and TEMPO as a mild oxidant to give N-protected 2-aryl-2-alkyl-3-(2-chloroacetoxy)indolines is described. Reactions are easy to conduct, and product indolines containing a fully substituted C-center are obtained in good yields with good to excellent selectivities.