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Relevant academic research and scientific papers

Mechanochemical Solvent-Free Synthesis of Indenones from Aromatic Carboxylic Acids and Alkynes

The mechanochemical solvent-free synthesis of indenones from aromatic carboxylic acids and alkynes was achieved through triflic anhydride (Tf2O)-induced cyclization reaction. A variety of indenones including a bioactive PPARγagonist were obtained in up to 90% yield at room temperature. The present protocol has the advantages of mild reaction conditions, high reaction efficiency, and feasibility of scalable synthesis, providing a facile and sustainable route to diverse indenones.

Synthesis of indenones through rhodium(III)-catalyzed [3+2] annulation utilizing a recyclable carbazolyl leaving group

The rhodium(III)-catalyzed annulative coupling of 9-ben-zoylcarbazoles with internal alkynes proceeds efficiently through ortho CH and CN bond cleavages. This reaction provides direct access to variously substituted indanone derivatives. The carbazolyl leaving group can be readily recovered and reused for preparing the starting materials.

Preparation method of polysubstituted indanone derivative

The invention relates to a polysubstituted indanone derivative and a preparation method thereof, and belongs to the technical field of organic synthesis. The preparation method comprises the followingsteps: in a solvent, reacting aryl aldehyde with an alkyne derivative under an illumination condition, and carrying out post-treatment to generate the polysubstituted indanone derivative. The methodhas the advantages of simple operation, environmental friendliness, high regioselectivity, low cost, mild reaction conditions, simple operation, wide substrate range, simple post-treatment, high yield, high purity and the like.

Divergent Synthesis of α-Aroyloxy Ketones and Indenones: A Controlled Domino Radical Reaction for Di- A nd Trifunctionalization of Alkynes

Three different modes of aldehyde/alkyne assembly through a controlled radical reaction are devised. While a double C-H activation/annulation leads to indenones, a concurrent oxidation of both aldehydes and alkynes in the course of their connection offers

Efficient synthesis method of 2,3-indanone

The invention discloses an efficient synthesis method of 2,3-indanone. A heating reaction is carried out on o-substituted benzaldehyde and alkyne in an organic solvent under the catalysis of nickel and a phosphine ligand under the action of an alkali to obtain a 2,3-indanone product. O-substituted benzaldehyde and alkyne are used as raw materials, and the 2,3-indanone product is obtained in one step under the catalysis of metal nickel and the phosphine ligand under the action of the alkali, so the operation is simple and convenient, the regioselectivity is high, and the method is cheap and hasa good application prospect, and can be applied to efficient synthesis of natural products, medicines and materials.

Ferrocene-Initiated Oxidative Cyclization of Benzaldehyde with Alkyne: New Strategy to Substituted Indenones

A ferrocene-initiated oxidative cyclization of benzaldehyde with alkyne was successfully developed as a novel strategy for direct access to substituted indenones in high yields. The commercially available and cheap ferrocene was employed as an initiator. This transformation could proceed smoothly with a low initiator loading (0.5 mol-%) and provide the titled products up to 90 % yield with atom-, step-economy and good substrates tolerance. The indenones obtained would be important building blocks in organic synthesis.

A polysubstituted indenone derivatives and its preparation method (by machine translation)

The present invention discloses a multi-substituted indenone derivatives and its preparation method, its structural formula is: Wherein R1 Is alkyl, halogen, methoxy, trifluoromethyl, N, N - dimethyl or methylthio, R2 is aryl. Synthesis of this invention has a plurality of substituted base yinyin alkone derivatives, from the point of view of pharmaceutical chemistry has far-reaching significance. The method of this invention easily obtained raw material, economic low-cost, high yield, mild reaction conditions, wide substrate range, easy post treatment. (by machine translation)

Palladium(ii)-catalyzed synthesis of indenones through the cyclization of benzenecarbaldehydes with internal alkynes

The palladium(ii)-catalyzed carbocyclization of benzenecarbaldehydes with internal alkynes to afford 2,3-disubstituted indenones was reported. The annulation reaction proceeded through the transmetalation of Pd(ii) with an aromatic aldehyde and the insertion of internal alkynes, followed by cyclization via the intramolecular nucleophilic addition of intermediate organopalladium(ii) species to the aldehyde group. This reaction proceeded in moderate to good yields with high regioselectivity.

Rhodium-Catalyzed Oxidative Decarboxylation Annulation Reactions of Mandelic Acids and Alkynes: An Efficient Synthetic Method for Indenones

Efficient rhodium-catalyzed oxidative decarboxylation annulation reactions between mandelic acids and alkyne derivatives are described. The desired indenone products were obtained in medium to good yields under the optimized reaction conditions, which were a [RhCp*Cl2]2 catalyst (10.0 mol %) in combination with a PCy3 ligand (10.0 mol %) and AgSbF6 (10 mol %) and Cu(OAc)2 (20 mol %) additives. Many functional groups are compatible with the reaction under the optimized reaction conditions. This strategy provides a promising method for the construction of indenones from cheap and commercially available starting materials.

Cobalt(III)-catalyzed annulation of esters and alkynes: A facile route to indenones

An efficient protocol for the synthesis of indenones has been developed via the annulation of benzoic esters and internal alkynes by exploiting the cobalt catalyst.