53838-27-0

Basic information

• Product Name: L-Glutamic acid, 5-(1,1-dimethylethyl) 1-methyl ester
• Synonyms: AmbotzHAA6700
• CAS NO: 53838-27-0
• Molecular Formula: C10H19NO4
• Molecular Weight: 217.265
• Mol File: 53838-27-0.mol

Chemical Properties

• CAS DataBase Reference: L-Glutamic acid, 5-(1,1-dimethylethyl) 1-methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Glutamic acid, 5-(1,1-dimethylethyl) 1-methyl ester(53838-27-0)
• EPA Substance Registry System: L-Glutamic acid, 5-(1,1-dimethylethyl) 1-methyl ester(53838-27-0)

Safety Data

• Hazardous Substances Data: 53838-27-0(Hazardous Substances Data)

Upstream product

• 113408-54-1 trityl-glutamic acid-1-methyl ester 
• 6525-53-7 L-glutamic acid dimethyl ester 
• 56-86-0 L-glutamic acid 
• 113408-53-0 N-trityl-L-glutamic acid dimethyl ester 
• 160002-61-9 N-(9-fluorenylmethoxycarbonyl)glutamic acid (O-tert-butyl) methyl ester 
• 3886-08-6 5-tert-butyl N-benzyloxycarbonyl-L-glutamate 
• 4124-76-9 N-(benzyloxycarbonyl)-L-glutamic acid anhydride 
• 5672-83-3 Z-L-GluOMe 
• 186581-53-3 diazomethane 
• 2419-56-9 L-glutamic acid 5-tert-butyl ester 
• 56877-41-9 methyl 2(S)-2-benzyloxycarbonylamino-4-tert-butoxycarbonylbutanoate 

Downstream Products

• 294855-90-6 5-(2,5-dioxopyrrolidin-1-yl)-1-methylpalmitoyl L-glutamate 
• 73793-91-6 N-Hexadecanoyl-L-glutamic acid α-methyl ester 
• 1219595-87-5 C₂₃H₃₄N₂O₉ 
• 1018929-92-4 5-tert-butyl-1-methyl ester ((S)-2-{[3-(4-nitro-benzenesulfonylamino)thiophene-2-carbonyl]amino})pentanedioate 
• 115553-99-6 2(S),3'(S)-1-(3-amino-3-carboxypropyl)-5-oxo-2-pyrrolidinecarboxylic acid 
• 179682-17-8 4-(3-{1-[(S)-4-Methoxycarbonyl-4-(4-propyl-benzenesulfonylamino)-butyryl]-piperidin-4-yl}-propyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 179682-16-7 (S)-2-(4-Propyl-benzenesulfonylamino)-pentanedioic acid 1-methyl ester 
• 197969-50-9 (S)-4-[(3-Cyclohexyl-propyl)-methyl-carbamoyl]-4-{3-[6-(di-tert-butoxy-phosphoryloxy)-naphthalen-1-yl]-ureido}-butyric acid tert-butyl ester 
• 189393-64-4 (S)-4-[(3-Cyclohexyl-propyl)-methyl-carbamoyl]-4-[3-(6-hydroxy-naphthalen-1-yl)-ureido]-butyric acid tert-butyl ester 

Relevant articles and documents

Method for synthesizing glutamic acid-1-methyl ester-5-tert-butyl ester

The invention discloses a method for synthesizing glutamic acid-1-methyl ester-5-tert-butyl ester. The method comprises the following steps: generating dimethyl glutamate by using glutamic acid as aninitial raw material in methyl alcohol under the effect of thionyl chloride; reacting the dimethyl glutamate with triphenylchloromethane to generate dimethyl glutamate with triphenylmethyl protected amino; taking off methyl ester on the 5 position of the dimethyl glutamate with triphenylmethyl protected amino under the effect of sodium hydroxide to generate triphenylmethyl-glutamic acid-1-methyl ester; reacting the triphenylmethyl-glutamic acid-1-methyl ester-5-tert-butyl ester with trichloroacetic imine tert-butyl ester to generate triphenylmethyl-glutamic acid-1-methyl ester-5-tert-butyl ester, adding a small amount of triisopropylsilane into the triphenylmethyl-glutamic acid-1-methyl ester-5-tert-butyl ester in a low-concentration dichloromethane trifluoroacetate solution to take off triphenylmethyl to generate the glutamic acid-1-methyl ester-5-tert-butyl ester. The method is simple in operation, has few byproduct which can be extremely easy to treat and high product yield, and cansolve the problem of large operation difficulty in an existing synthesizing method.

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