491-79-2

Upstream product

• 480-47-7 hydrangenol 
• 13506-76-8 2-methyl-6-nitrobenzoic acid 
• 567-61-3 2-hydroxy-6-methylbenzoic acid 
• 438187-08-7 2, 2, 5-trimethyl-4H-benzo[d][1,3]dioxin-4-one 
• 507480-02-6 5-(bromomethyl)-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one 

Downstream Products

• 113345-84-9 methyl 2-methoxy-6-[2-(4-methoxyphenyl)ethenyl]benzoate 
• 23255-59-6 lunularic acid 
• 480-47-7 hydrangenol 
• 63877-76-9 (E)-4-<2-(3-hydroxyphenyl)ethenyl>phenol 
• 157598-00-0 (+/-)-hydromacrophyllol B 
• 157598-00-0 (+/-)-hydromacrophyllol A 
• 52528-89-9 3,4'-bis-benzoyloxy-bibenzyl 
• 37116-80-6 lunularin 
• 183619-44-5 8-(tert-Butyl-dimethyl-silanyloxy)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-isochroman-1-one 
• 183619-48-9 8-(tert-Butyl-dimethyl-silanyloxy)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-isochromen-1-one 
• 80458-94-2 3'-Deoxythunberginol A 

Relevant academic research and scientific papers

Valuable building block for the synthesis of lunularic acid, hydrangeic acid and their analogues

A new functionalised sulphone-based building block has been synthesised that enabled C-C bond formation through Julia olefination. The utility of developed building block was demonstrated by successful synthesis of two natural products lunularic acid, hydrangeic acid and initial libraries of their analogues.

Compositions containing hypotriglyceridemically active stilbenoids

The use of isolated or purified stilbenoid compounds including longistyline A-2-carboxylic acid as a dietary supplement to mammals suffering from elevated triglyceride levels is described. The invention also relates to the use of such stibenoid compounds in combination with other hypotriglyceridemic agents.

Development of bioactive functions in Hydrangeae Dulcis Folium. VI. Syntheses of thunberginols A and F and their 3'-deoxy-derivatives using regiospecific lactonization of stilbene carboxylic acid: Structures and inhibitory activity on histamine release of hydramacrophyllols A and B

Lactonization reaction of 2-carboxystilbene mediated by copper(II) chloride proceeded regiospecifically to give the five-membered lactone, while the bromolactonizations using N-bromosuccinimide and anodic oxidation were found to furnish the six-membered lactone. Using these regiospecific lactonization reactions as a key step, antiallergic and antimicrobial isocoumarins and the benzylidenephthalides thunberginols A and F and their 3'-deoxyanalogs were synthesized from phyllodulcin and hydrangenol. Two phthalides called hydramacrophyllols A and B were isolated from Hydrangeae Dulcis Folium and their stereostructures were determined on the basis of physicochemical and chemical evidence, which included the syntheses of hydramacrophyllols A and B from hydrangenol by the application of the lactonization method using copper(II) chloride. In addition, hydramacrophyllols A and B were found to exhibit an inhibitory effect on the histamine release from rat peritoneal exudate cells induced by antigen- antibody reaction.

Chemical transformation from dihydroisocoumarin into benzylidene-phthalide by use of regiospecific oxidative lactonization mediated by copper chloride (H) - Syntheses of thunberginol F and hydramacrophyllol A and B

Oxidative lactonization of 2-carboxystilbene mediated by CuCl2 proceeded regiospecifically to give the five-membered lactone. By utilizing this lactonization as a key reaction, chemical transformation from dihydroisocoumarine into benzylideneph