63877-76-9

Basic information

• Product Name: Phenol, 3-[2-(4-hydroxyphenyl)ethenyl]-, (E)-
• CAS NO: 63877-76-9
• Molecular Formula: C14H12O2
• Molecular Weight: 212.248
• Mol File: 63877-76-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Phenol, 3-[2-(4-hydroxyphenyl)ethenyl]-, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 3-[2-(4-hydroxyphenyl)ethenyl]-, (E)-(63877-76-9)
• EPA Substance Registry System: Phenol, 3-[2-(4-hydroxyphenyl)ethenyl]-, (E)-(63877-76-9)

Safety Data

• Hazardous Substances Data: 63877-76-9(Hazardous Substances Data)

Upstream product

• 1236211-29-2 (E)-3-(4-acetoxystyryl)phenyl acetate 
• 540-38-5 p-Iodophenol 
• 620-18-8 3-hydroxystyrene 
• 33527-94-5 4-acetoxyiodobenzene 
• 2454-30-0 3-vinylphenyl acetate 
• 100-42-5 styrene 
• 626-02-8 3-Iodophenol 
• 836-43-1 4-benzyloxybenzyl alcohol 
• 4397-53-9 p-benzyloxybenzaldehyde 
• 491-79-2 Hydrangeaic acid 
• 150258-73-4 (E)-1-<3-(benzyloxy)phenyl>-2-<4-(benzyloxy)phenyl>ethene 
• 39032-14-9 1-[(E)-2-(4-methoxyphenyl)ethenyl]-3-methoxybenzene 
• 1530-38-7 ((4-methoxyphenyl)methyl)triphenylphosphonium bromide 
• 131719-55-6 diethyl <4-(benzyloxy)benzyl>phosphonate 

Downstream Products

• 39032-14-9 1-[(E)-2-(4-methoxyphenyl)ethenyl]-3-methoxybenzene 

Relevant articles and documents

Galloyl esters of trans-stilbenes are inhibitors of FASN with anticancer activity on non-small cell lung cancer cells

Fatty acid synthase (FASN) is a lipogenic enzyme that is selectively upregulated in malignant cells. There is growing consensus on the oncogenicity of FASN-driven lipogenesis and the potential of FASN as a druggable target in cancer. Here, we report the synthesis and FASN inhibitory activities of two novel galloyl esters of trans-stilbene EC1 and EC5. Inhibition of FASN was accompanied by a loss in AKT activation and profound apoptosis in several non-small cell lung cancer (NSCLC) cells at the growth inhibitory concentrations of EC1 and EC5. Both FASN and phospho-AKT levels were concurrently downregulated. However, addition of a lipid concentrate to the treated cells reinstated cell viability and reversed the loss of FASN and AKT protein levels, thus recapitulating the causal relationship between FASN inhibition and the loss in cell viability.

A facile and rapid access to resveratrol derivatives and their radioprotective activity

A facile and rapid access to resveratrol derivatives has been achieved based on palladium-catalyzed oxidative Heck reaction of aryl boronic acids with styrenes followed by demethylation in moderate to good yields. A series of resveratrol derivatives with various functional groups has been synthesized easily. The radioprotective activity of synthesized compounds has also been evaluated using rat thymocytes. The results revealed that some resveratrol derivatives efficiently protected the thymocytes from radiation-induced apoptosis.

Synthesis and Protein-Tyrosine Kinase Inhibitory Activity of Polyhydroxylated Stilbene Analogues of Piceatannol

A series of hydroxylated trans-stilbene related to the antileukemic natural product trans-3,3',4,5'-tetrahydroxy stilbene (piceatannol) (1) has been prepared and tested for inhibition of the lymphoid cell lineage-specific protein-tyrosine kinase p56lck, which plays an important role in lymphocyte proliferation and immune function.A number of the analogues displayed enhanced enzyme inhibitory activity relative to the natural product.Reduction of the double bond bridging the two aromatic rings and benzylation of the phenolic hydroxyl groups was found to decrease activity significantly.The most potent compounds in the series proved to be trans-3,3',5,5'-tetrahydroxystilbene, trans-3,3',5-trihydroxystilbene, and trans-3,4,4'-trihydroxystilbene.