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(3aS,4R,6aR)-6-(benzyloxymethyl)-5-fluoro-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-ol is a chiral fluorinated cyclopentane derivative that features a benzyl ether group. This complex molecule is characterized by its specific stereochemistry, with a fluorine atom and a hydroxyl group attached to the cyclopentane ring, which may contribute to its potential pharmacological or biological activities and applications in organic synthesis.

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  • (3aS,4R,6aR)-6-[(benzyloxy)methyl]-5-fluoro-2,2-dimethyl-2H,3aH,4H,6aH-cyclopenta[d][1,3]dioxol-4-ol;491578-02-0

    Cas No: 491578-02-0

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  • Amadis Chemical Co., Ltd.
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  • (3aS,4R,6aR)-6-[(benzyloxy)methyl]-5-fluoro-2,2-dimethyl-2H,3aH,4H,6aH-cyclopenta[d][1,3]dioxol-4-ol

    Cas No: 491578-02-0

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  • (3aS,4R,6aR)-6-(benzyloxymethyl)-5-fluoro-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-ol

    Cas No: 491578-02-0

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  • (3AS,4R,6AR)-6-((BENZYLOXY)METHYL)-5-FLUORO-2,2-DIMETHYL-4,6A-DIHYDRO-3AH-CYCLOPENTA[D][1,3]DIOXOL-4-OL

    Cas No: 491578-02-0

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  • coolpharm Ltd
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  • 491578-02-0 Structure
  • Basic information

    1. Product Name: (3aS,4R,6aR)-6-(benzyloxymethyl)-5-fluoro-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-ol
    2. Synonyms: (3aS,4R,6aR)-6-(benzyloxymethyl)-5-fluoro-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-ol
    3. CAS NO:491578-02-0
    4. Molecular Formula:
    5. Molecular Weight: 294.323
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 491578-02-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (3aS,4R,6aR)-6-(benzyloxymethyl)-5-fluoro-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-ol(CAS DataBase Reference)
    10. NIST Chemistry Reference: (3aS,4R,6aR)-6-(benzyloxymethyl)-5-fluoro-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-ol(491578-02-0)
    11. EPA Substance Registry System: (3aS,4R,6aR)-6-(benzyloxymethyl)-5-fluoro-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-ol(491578-02-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 491578-02-0(Hazardous Substances Data)

491578-02-0 Usage

Uses

Used in Pharmaceutical Industry:
(3aS,4R,6aR)-6-(benzyloxymethyl)-5-fluoro-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-ol is used as a potential pharmaceutical candidate for [application reason] due to its unique structural features and potential biological activities.
Used in Organic Synthesis:
In the field of organic synthesis, (3aS,4R,6aR)-6-(benzyloxymethyl)-5-fluoro-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-ol serves as a valuable intermediate or building block for the development of new compounds with specific properties and applications.
(Note: The specific application reasons and details would require further research and investigation to be accurately determined.)

Check Digit Verification of cas no

The CAS Registry Mumber 491578-02-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,9,1,5,7 and 8 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 491578-02:
(8*4)+(7*9)+(6*1)+(5*5)+(4*7)+(3*8)+(2*0)+(1*2)=180
180 % 10 = 0
So 491578-02-0 is a valid CAS Registry Number.

491578-02-0Relevant articles and documents

6′-Fluoro-3-deazaneplanocin: Synthesis and antiviral properties, including Ebola

Liu, Chong,Chen, Qi,Cardinale, Steven,Bowlin, Terry L.,Schneller, Stewart W.

, p. 3674 - 3675 (2018/11/03)

A convenient stereospecific synthesis of 6′-fluoro-3-deazaneplanocin (6) has been accomplished from D-ribose in 15 steps. It is reported to possess significant activity towards Ebola (Zaire, Vero, μM: EC50 50 125; SI > 347)

Regio- and stereoselective synthesis of 2′-β-substituted-fluoroneplanocin A analogues as potential anticancer agents

Nayak, Akshata,Sahu, Pramod K.,Song, Jayoung,Lee, Sang Kook,Jeong, Lak Shin

, p. 9236 - 9248 (2015/09/07)

A series of 2′-β-substituted-6′-fluoro-cyclopentenyl-pyrimidines and -purines 8 and 9 were successfully synthesized from D-ribose in a regio- and stereoselective manner. The functionalization at the C2-position of 6′-fluoro-cyclopentenyl nucleosides was a

Fluorocyclopentenyl-cytosine with broad spectrum and potent antitumor activity

Choi, Won Jun,Chung, Hwa-Jin,Chandra, Girish,Alexander, Varughese,Zhao, Long Xuan,Lee, Hyuk Woo,Nayak, Akshata,Majik, Mahesh S.,Kim, Hea Ok,Kim, Jin-Hee,Lee, Young B.,Ahn, Chang H.,Lee, Sang Kook,Jeong, Lak Shin

, p. 4521 - 4525 (2012/08/13)

On the basis of the potent biological activity of cyclopentenyl- pyrimidines, fluorocyclopentenyl-pyrimidines were designed and synthesized from d-ribose. Among these, the cytosine derivative 5a showed highly potent antigrowth effects in a broad range of

X-ray crystal structure and binding mode analysis of human S-adenosylhomocysteine hydrolase complexed with novel mechanism-based inhibitors, haloneplanocin A analogues

Lee, Kang Man,Choi, Won Jun,Lee, Yoonji,Lee, Hyun Joo,Zhao, Long Xuan,Lee, Hyuk Woo,Park, Jae Gyu,Kim, Hea Ok,Hwang, Kwang Yeon,Heo, Yong-Seok,Choi, Sun,Jeong, Lak Shin

, p. 930 - 938 (2011/04/24)

The X-ray crystal structure of human S-adenosylhomocysteine (AdoHcy) hydrolase was first determined as a tetrameric form bound with the novel mechanism-based inhibitor fluoroneplanocin A (4b). The crystallized enzyme complex showed the closed conformation

Synthesis and antitumor activity of fluorocyclopentenyl-pyrimidines

Jeong, Lak Shin,Zhao, Long Xuan,Choi, Won Jun,Pal, Shantanu,Park, Yeon Hee,Lee, Sang Kook,Chun, Moon Woo,Lee, Young B.,Ahn, Chang Ho,Moon, Hyung Ryong

, p. 713 - 716 (2008/03/27)

Synthesis of fluorocyclopentenyl pyrimidine nucleosides 6-9 was enantiopurely accomplished employing oxidative rearrangement, RCM reaction and electrophilic fluorination starting from D-ribose. Cytosine analog 8 was found to exhibit significant anticancer

Synthesis and biological evaluation of halo-neplanocin A as novel mechanism-based inhibitors of S-Adenosylhomocysteine hydrolase

Jeong, Lak Shin,Moon, Hyung Ryong,Park, Jae Gyu,Shin, Dae Hong,Choi, Won Jun,Lee, Kang Man,Kim, Hea Ok,Chun, Moon Woo,Kim, Hee-Doo,Kim, Joong Hyup

, p. 589 - 592 (2007/10/03)

Halogenated analogues of neplanocin A were synthesized from the key intermediate 1, among which fluoro-neplanocin A was found to be novel mechanism-based irreversible inhibitor of S-Adenosylhomocysteine hydrolase.

Design, synthesis, and biological evaluation of fluoroneplanocin A as the novel mechanism-based inhibitor of S-adenosylhomocysteine hydrolase

Jeong, Lak Shin,Yoo, Su Jeong,Lee, Kang Man,Koo, Mi Jeong,Choi, Won Jun,Kim, Hea Ok,Moon, Hyung Ryong,Lee, Min Young,Park, Jae Gyu,Lee, Sang Kook,Chun, Moon Woo

, p. 201 - 203 (2007/10/03)

Fluoroneplanocin A (12) was designed as a novel mechanism-based inhibitor of S-adenosylhomocysteine hydrolase (SAH) and efficiently synthesized via an electrophilic vinyl fluorination reaction (n-BuLi, N-fluorobenzenesulfonimide at -78 °C). Fluoroneplanoc

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