117307-62-7Relevant articles and documents
Fluorocyclopentenyl-cytosine with broad spectrum and potent antitumor activity
Choi, Won Jun,Chung, Hwa-Jin,Chandra, Girish,Alexander, Varughese,Zhao, Long Xuan,Lee, Hyuk Woo,Nayak, Akshata,Majik, Mahesh S.,Kim, Hea Ok,Kim, Jin-Hee,Lee, Young B.,Ahn, Chang H.,Lee, Sang Kook,Jeong, Lak Shin
, p. 4521 - 4525 (2012/08/13)
On the basis of the potent biological activity of cyclopentenyl- pyrimidines, fluorocyclopentenyl-pyrimidines were designed and synthesized from d-ribose. Among these, the cytosine derivative 5a showed highly potent antigrowth effects in a broad range of
Preparative and Stereoselective Synthesis of the Versatile Intermediate for Carbocyclic Nucleosides: Effects of the Bulky Protecting Groups to Enforce Facial Selectivity
Choi, Won Jun,Moon, Hyung Ryong,Kim, Hea Ok,Yoo, Byul Nae,Lee, Jeong A.,Shin, Dae Hong,Jeong, Lak Shin
, p. 2634 - 2636 (2007/10/03)
The preparative and stereoselective synthesis (45-50% overall yields) of the target compound 17 has been accomplished from D-ribose. The bulky protecting groups such as TBDPS and Trityl enforced the facial selectivity during Grignard reaction to give the
Synthesis using ring closure metathesis and effect on nucleoside transport of a (N)-methanocarba S-(4-nitrobenzyl)thioinosine derivative
Lee, Kyeong,Cass, Carol,Jacobson, Kenneth A.
, p. 597 - 599 (2007/10/03)
(Matrix presented) A new synthetic route to ring-constrained (N)-methanocarba nucleosides and nucleotides is presented. Ring closure of a diene intermediate usina Grubbs catalyst provides a new avenue for the preparation of the cyclopentenone derivative 6
