952418-10-9Relevant articles and documents
Preparative and Stereoselective Synthesis of the Versatile Intermediate for Carbocyclic Nucleosides: Effects of the Bulky Protecting Groups to Enforce Facial Selectivity
Choi, Won Jun,Moon, Hyung Ryong,Kim, Hea Ok,Yoo, Byul Nae,Lee, Jeong A.,Shin, Dae Hong,Jeong, Lak Shin
, p. 2634 - 2636 (2004)
The preparative and stereoselective synthesis (45-50% overall yields) of the target compound 17 has been accomplished from D-ribose. The bulky protecting groups such as TBDPS and Trityl enforced the facial selectivity during Grignard reaction to give the
Fluorocyclopentenyl-cytosine with broad spectrum and potent antitumor activity
Choi, Won Jun,Chung, Hwa-Jin,Chandra, Girish,Alexander, Varughese,Zhao, Long Xuan,Lee, Hyuk Woo,Nayak, Akshata,Majik, Mahesh S.,Kim, Hea Ok,Kim, Jin-Hee,Lee, Young B.,Ahn, Chang H.,Lee, Sang Kook,Jeong, Lak Shin
scheme or table, p. 4521 - 4525 (2012/08/13)
On the basis of the potent biological activity of cyclopentenyl- pyrimidines, fluorocyclopentenyl-pyrimidines were designed and synthesized from d-ribose. Among these, the cytosine derivative 5a showed highly potent antigrowth effects in a broad range of
Total syntheses of a conformationally locked North-type methanocarba puromycin analogue and a dinucleotide derivative
Michel, Benoit Y.,Strazewski, Peter
supporting information; experimental part, p. 6244 - 6257 (2010/03/26)
An original synthetic approach for the first synthesis of an enantiopure methanocarba puromycin (3'-α-aminoacylamino-3'-deoxyadenosine) analogue and its cytidine dinucleotide derivative is described. Each compound is conformationally locked in a North-typ
Synthesis of (-)-neplanocin A with the highest overall yield via an efficient Mitsunobu coupling
Michel, Beno?t Y.,Strazewski, Peter
, p. 9836 - 9841 (2008/02/11)
Neplanocin A was synthesized in very high isolated yield and purity, in 10 steps from d-ribose via an efficient Mitsunobu coupling using N6-bis-Boc-protected adenine. In fact, this synthesis is a short pathway to enantiopure neplanocin A giving