4917-74-2

Usage

Type

Synthetic organic compound

Use

Carbonic anhydrase inhibitor in the treatment of glaucoma, epilepsy, and certain types of edema

Mechanism of action

Inhibits the enzyme carbonic anhydrase, reducing production of aqueous humor in the eye and regulating pH in the brain and other tissues

Forms available

Oral and injectable

Side effects

Drowsiness, fatigue, loss of appetite

Upstream product

• 98777-16-3 2-benzoyloxy-1-butyronitrile 
• 102-71-6 triethanolamine 
• 19172-47-5 Lawessons reagent 
• 23427-66-9 2-benzoyloxy-propionic acid amide 
• 98-88-4 benzoyl chloride 

Downstream Products

• 21478-61-5 benzoic acid-(1-thiazol-2-yl-ethyl ester) 
• 100956-45-4 2-[2-(1-benzoyloxy-ethyl)-4-methyl-thiazol-5-yl]-ethanol 
• 849048-44-8 1-benzoyloxy-1-(4-phenyl-thiazol-2-yl)-ethane 
• 408318-86-5 1-benzoyloxy-1-(4-methyl-thiazol-2-yl)-ethane 
• 76275-85-9 ethyl 2-<1-(benzoyloxy)ethyl>thiazole-4-carboxylate 
• 2409-45-2 1-benzoyloxy-1-[4-(4-nitro-phenyl)-thiazol-2-yl]-ethane 
• 80337-75-3 2'-<1-(benzyloxy)ethyl>-2,4'-bithiazole-4-carboxylate 
• 65823-87-2 1-(4-p-tolyl-thiazol-2-yl)-ethanol 

Relevant academic research and scientific papers

Total synthesis of myxothiazols, novel bis-thiazole β-methoxyacrylate- based anti-fungal compounds from myxobacteria

Convergent total syntheses of myxothiazols A and Z are described. The syntheses are based on elaboration of the (S)-E,E-diene thioamide 22, conversion of 22 into the bis-thiazole 27 and Wittig reactions between 27c and the aldehyde 30. The substituted β-m

MEDICINAL COMPOSITIONS

The present invention relates to an agent for the prophylaxis or treatment of pain, an agent for suppressing activation of osteoclast, and an inhibitor of osteoclast formation, which contains a p38 MAP kinase inhibitor and/or a TNF-α production inhibitor.

Substituted 1,3-thiazole compounds, their production and use

(1) A 1,3-thiazole compound of which the 5-position is substituted with a 4-pyridyl group having a substituent including no aromatic group or (2) a 1,3-thiazole compound of which the 5-position is substituted with a pyridyl group having at the position adjacent to a nitrogen atom of the pyridyl group a substituent including no aromatic group has an excellent p38 MAP kinase inhibitory activity.

A Convenient Synthesis of Methyl 2-thazoline-4-carboxylate, an Important Skeleton of Cyclothiazomycin

The convenient syntheses of a few methyl 2-(1-amino)alkenyl thiazoline-4-carboxylates and methyl 2-thiazoline-4-carboxylate have been accomplished.The latter is an important portial skeleton of macrobicyclic peptide antibiotic cyclothiazomycin.