491876-01-8 Usage
General Description
5-Methyl-3-phenyl-4-isoxazolylboronic acid is a boronic acid derivative with the chemical formula C10H11BNO3. It is a white to off-white powder that is used as a reagent in organic synthesis, particularly in the formation of carbon-carbon and carbon-heteroatom bonds. 5-METHYL-3-PHENYL-4-ISOXAZOLYLBORONIC ACID has been utilized in cross-coupling reactions and Suzuki-Miyaura coupling reactions to form biaryl compounds. It is also used in the pharmaceutical industry as a building block for the synthesis of various drug molecules. Additionally, 5-Methyl-3-phenyl-4-isoxazolylboronic acid has been investigated for its potential biological and pharmacological properties.
Check Digit Verification of cas no
The CAS Registry Mumber 491876-01-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,9,1,8,7 and 6 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 491876-01:
(8*4)+(7*9)+(6*1)+(5*8)+(4*7)+(3*6)+(2*0)+(1*1)=188
188 % 10 = 8
So 491876-01-8 is a valid CAS Registry Number.
InChI:InChI=1/C10H10BNO3/c1-7-9(11(13)14)10(12-15-7)8-5-3-2-4-6-8/h2-6,13-14H,1H3
491876-01-8Relevant articles and documents
Convenient Approach to 3,4-Diarylisoxazoles Based on the Suzuki Cross-Coupling Reaction
Dileep Kumar,Ho, ManKit M.,Leung, Jennifer M.,Toyokuni, Tatsushi
, p. 1146 - 1151 (2007/10/03)
The Suzuki cross-coupling reaction was found effective for rapid access to a series of 3,4-diarylisoxazoles of pharmacological interest. The efficiency of this approach was demonstrated by the synthesis of the highly potent COX-2-selective inhibitor, 4-(5-methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide (valdecoxib), and its analogues. Thus, the coupling reaction between (3-aryl-5-methyl-4-isoxazolyl)boronic acids, prepared in situ from the corresponding bromides using triisopropyl borate, and aryl bromides containing a 4-sulfonamide or 4-methylsulfonyl group under the standard conditions [Pd(PPh3)4, Na2CO3, EtOH-H2O, reflux] yielded the target 3,4-diarylisoxazoles in good yields.
