491876-01-8 Usage
Uses
Used in Organic Synthesis:
5-METHYL-3-PHENYL-4-ISOXAZOLYLBORONIC ACID is used as a reagent for the formation of carbon-carbon and carbon-heteroatom bonds in organic synthesis. Its ability to participate in cross-coupling reactions and Suzuki-Miyaura coupling reactions makes it a valuable component in the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-METHYL-3-PHENYL-4-ISOXAZOLYLBORONIC ACID is used as a building block for the synthesis of various drug molecules. Its unique structure and reactivity contribute to the development of new pharmaceutical compounds with potential therapeutic applications.
Used in Research and Development:
5-METHYL-3-PHENYL-4-ISOXAZOLYLBORONIC ACID is also used in research and development for investigating its potential biological and pharmacological properties. Its exploration in this field may lead to the discovery of new applications and therapeutic uses in medicine.
Used in Chemical Industry:
In the chemical industry, 5-METHYL-3-PHENYL-4-ISOXAZOLYLBORONIC ACID is utilized in the synthesis of various chemical compounds, including those with potential applications in materials science, agrochemicals, and other specialized fields. Its versatility as a reagent makes it a valuable asset in the development of new chemical products.
Check Digit Verification of cas no
The CAS Registry Mumber 491876-01-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,9,1,8,7 and 6 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 491876-01:
(8*4)+(7*9)+(6*1)+(5*8)+(4*7)+(3*6)+(2*0)+(1*1)=188
188 % 10 = 8
So 491876-01-8 is a valid CAS Registry Number.
InChI:InChI=1/C10H10BNO3/c1-7-9(11(13)14)10(12-15-7)8-5-3-2-4-6-8/h2-6,13-14H,1H3
491876-01-8Relevant academic research and scientific papers
Convenient Approach to 3,4-Diarylisoxazoles Based on the Suzuki Cross-Coupling Reaction
Dileep Kumar,Ho, ManKit M.,Leung, Jennifer M.,Toyokuni, Tatsushi
, p. 1146 - 1151 (2007/10/03)
The Suzuki cross-coupling reaction was found effective for rapid access to a series of 3,4-diarylisoxazoles of pharmacological interest. The efficiency of this approach was demonstrated by the synthesis of the highly potent COX-2-selective inhibitor, 4-(5-methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide (valdecoxib), and its analogues. Thus, the coupling reaction between (3-aryl-5-methyl-4-isoxazolyl)boronic acids, prepared in situ from the corresponding bromides using triisopropyl borate, and aryl bromides containing a 4-sulfonamide or 4-methylsulfonyl group under the standard conditions [Pd(PPh3)4, Na2CO3, EtOH-H2O, reflux] yielded the target 3,4-diarylisoxazoles in good yields.
