31295-65-5 Usage
Uses
Used in Pharmaceutical Industry:
4-Bromo-5-methyl-3-phenylisoxazole is used as a pharmaceutical compound for its antimicrobial, antiviral, and antibacterial properties. Its potential applications in this industry include the development of new drugs to combat various infections and diseases.
Used in Agrochemical Industry:
In the agrochemical industry, 4-Bromo-5-methyl-3-phenylisoxazole is utilized as an active ingredient in pesticides and fungicides, leveraging its antimicrobial and antibacterial properties to protect crops from harmful pathogens.
Used in Organic Synthesis:
4-Bromo-5-methyl-3-phenylisoxazole serves as a building block in organic synthesis, enabling the development of new compounds with diverse biological and medicinal activities. Its unique structure and properties make it a valuable component in the synthesis of innovative pharmaceuticals and agrochemicals.
Used in Research and Development:
4-BroMo-5-Methyl-3-phenylisoxazole's potential for further research and development is significant, as it can be explored for its uses in various industries and scientific fields. This includes the investigation of its biological activities, potential applications in drug delivery systems, and its role in the synthesis of novel compounds with therapeutic or agricultural benefits.
Check Digit Verification of cas no
The CAS Registry Mumber 31295-65-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,1,2,9 and 5 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 31295-65:
(7*3)+(6*1)+(5*2)+(4*9)+(3*5)+(2*6)+(1*5)=105
105 % 10 = 5
So 31295-65-5 is a valid CAS Registry Number.
31295-65-5Relevant academic research and scientific papers
Oxime-mediated facile access to 5-methylisoxazoles and applications in the synthesis of valdecoxib and oxacillin
Dong, Kui-Yong,Qin, Hai-Tao,Bao, Xing-Xing,Liu, Feng,Zhu, Chen
supporting information, p. 5266 - 5268 (2015/01/09)
A palladium-catalyzed efficient synthesis of 5-methylisoxazoles via oxime-mediated functionalization of unactivated olefins is described. The reaction affords a variety of 5-methylisoxazoles in moderate to good yields. To further demonstrate the utility of the method, the rapid synthesis of valdecoxib and oxacillin is reported. (Chemical Equation Presented).
KINASE INHIBITORS
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Page/Page column 47, (2010/02/13)
ABSTRACT The present invention provides kinase inhibitors of Formula I: .
Convenient Approach to 3,4-Diarylisoxazoles Based on the Suzuki Cross-Coupling Reaction
Dileep Kumar,Ho, ManKit M.,Leung, Jennifer M.,Toyokuni, Tatsushi
, p. 1146 - 1151 (2007/10/03)
The Suzuki cross-coupling reaction was found effective for rapid access to a series of 3,4-diarylisoxazoles of pharmacological interest. The efficiency of this approach was demonstrated by the synthesis of the highly potent COX-2-selective inhibitor, 4-(5-methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide (valdecoxib), and its analogues. Thus, the coupling reaction between (3-aryl-5-methyl-4-isoxazolyl)boronic acids, prepared in situ from the corresponding bromides using triisopropyl borate, and aryl bromides containing a 4-sulfonamide or 4-methylsulfonyl group under the standard conditions [Pd(PPh3)4, Na2CO3, EtOH-H2O, reflux] yielded the target 3,4-diarylisoxazoles in good yields.
