491876-03-0

Basic information

• Product Name: Boronic acid, [4-[[[bis(4-methoxyphenyl)phenylmethyl]amino]sulfonyl]-3-fluorophenyl]-
• CAS NO: 491876-03-0
• Molecular Formula: C27H25BFNO6S
• Molecular Weight: 521.374
• Mol File: 491876-03-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Boronic acid, [4-[[[bis(4-methoxyphenyl)phenylmethyl]amino]sulfonyl]-3-fluorophenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Boronic acid, [4-[[[bis(4-methoxyphenyl)phenylmethyl]amino]sulfonyl]-3-fluorophenyl]-(491876-03-0)
• EPA Substance Registry System: Boronic acid, [4-[[[bis(4-methoxyphenyl)phenylmethyl]amino]sulfonyl]-3-fluorophenyl]-(491876-03-0)

Safety Data

• Hazardous Substances Data: 491876-03-0(Hazardous Substances Data)

Upstream product

• 214210-30-7 4-bromo-2-fluorobenzenesulfonamide 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 491876-10-9 4-bromo-N-(4,4'-dimethoxytrityl)-2-fluorobenzenesulfonamide 

Downstream Products

• 30058-40-3 2-fluorobenzenesulfonamide 

Relevant articles and documents

Convenient Approach to 3,4-Diarylisoxazoles Based on the Suzuki Cross-Coupling Reaction

The Suzuki cross-coupling reaction was found effective for rapid access to a series of 3,4-diarylisoxazoles of pharmacological interest. The efficiency of this approach was demonstrated by the synthesis of the highly potent COX-2-selective inhibitor, 4-(5-methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide (valdecoxib), and its analogues. Thus, the coupling reaction between (3-aryl-5-methyl-4-isoxazolyl)boronic acids, prepared in situ from the corresponding bromides using triisopropyl borate, and aryl bromides containing a 4-sulfonamide or 4-methylsulfonyl group under the standard conditions [Pd(PPh3)4, Na2CO3, EtOH-H2O, reflux] yielded the target 3,4-diarylisoxazoles in good yields.