30058-40-3

Usage

Uses

Used in Pharmaceutical Industry:
2-Fluorobenzenesulfonamide is used as an intermediate for the synthesis of various pharmaceutical compounds. Its unique chemical structure allows it to be a versatile building block in the development of new drugs, particularly those targeting specific biological pathways.
Used in Chemical Synthesis:
2-Fluorobenzenesulfonamide is used as a reagent in the chemical synthesis of various organic compounds. Its fluorinated nature and benzene ring make it a valuable component in the creation of complex molecules for research and industrial applications.
Used in Research and Development:
2-Fluorobenzenesulfonamide is used as a research compound for studying the effects of fluorination on the properties and reactivity of benzene-based molecules. This can lead to a better understanding of the role of fluorine in chemical reactions and the development of new synthetic methods.
Used in Material Science:
2-Fluorobenzenesulfonamide can be used in the development of new materials with specific properties, such as improved thermal stability or chemical resistance. Its unique structure and properties make it a potential candidate for use in the creation of advanced materials for various applications.
Used in Analytical Chemistry:
2-Fluorobenzenesulfonamide can be used as a reference compound or standard in analytical chemistry for the calibration of instruments and the development of new analytical methods. Its distinct chemical properties make it a valuable tool for researchers in this field.

InChI:InChI=1/C6H6FNO2S/c7-5-3-1-2-4-6(5)11(8,9)10/h1-4H,(H2,8,9,10)

Upstream product

• 127159-66-4 sodium 2-fluorobenzenesulfinate 
• 2905-21-7 2-fluorobenzenesulfonyl chloride 
• 491876-10-9 4-bromo-N-(4,4'-dimethoxytrityl)-2-fluorobenzenesulfonamide 
• 214210-30-7 4-bromo-2-fluorobenzenesulfonamide 
• 491876-03-0 C₂₇H₂₅BFNO₆S 
• 31295-65-5 4-bromo-5-methyl-3-phenylisoxazole 

Downstream Products

• 87028-94-2 2-(2-methoxyethylthio)benzenesulfonamide 
• 1057257-46-1 C₂₈H₂₁FN₂O₄S 
• 851169-58-9 2-fluoro-N-methylbenzenesulfonamide 
• 1602577-61-6 N-(2-fluorophenylsulfonyl)-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxamide 
• 1153316-36-9 2-(cyclopropylamino)benzenesulfonamide 
• 131269-61-9 2-(piperidin-1-yl)benzenesulfonamide 
• 1130321-19-5 C₂₆H₁₉ClFN₅O₄S 
• 1112980-01-4 N-(6-(2-(2-fluorophenylsulfonamido)pyrimidin-4-yl)benzo[d]thiazol-2-yl)acetamide 
• 131269-60-8 2-pyrrolidino-benzenesulphonamide 

Relevant academic research and scientific papers

NOVEL OXADIAZOLES

The present invention relates to novel oxadiazoles of Formula I, wherein, R1, L1, A, L2 and R10 are as defined in the detailed description.

Sulfonamide formation from sodium sulfinates and amines or ammonia under metal-free conditions at ambient temperature

A novel, practical and highly efficient method for the construction of a variety of sulfonamides mediated by I2 was demonstrated. The reaction proceeds readily at room temperature using a variety of sodium sulfinates and amines or ammonia in water in a metal-, base-, ligand-, or additive-free protocol. Primary, secondary and tertiary sulfonamides were obtained in good to excellent yields with a broad range of functional group tolerability. This journal is

Design and synthesis of triazolopyrimidine acylsulfonamides as novel anti-mycobacterial leads acting through inhibition of acetohydroxyacid synthase

Novel triazolopyrimidine acylsulfonamides class of antimycobacterial agents, which are mycobacterial acetohydroxyacid synthase (AHAS) inhibitors were designed by hybridization of known AHAS inhibitors such as sulfonyl urea and triazolopyrimidine sulfonamides. This Letter describes the synthesis and SAR studies of this class of molecules by variation of two parts of the molecule, the phenyl and triazolopyrimidine rings. SAR study describes optimisation of enzyme potency, whole cell potency and evidence of mechanism of action.

Cycloalkylated benzothiadiazines, a process for their preparation and pharmaceutical compostions containing them

Compounds of formula (I): wherein: RCy represents an unsubstituted or substituted cycloalkyl group or cycloalkylalkyl group,R1, R2, R3 and R4, which may be the same or different, each represent a hydrogen or halogen atom or a nitro group; a cyano group; a hydroxy group; an alkoxy group; an alkyl group; an unsubstituted or substituted amino group; a carboxy group; an alkoxycarbonyl group; an aryloxycarbonyl group; an unsubstituted or substituted aminocarbonyl group. Medicinal products containing the same which are useful in treating or preventing conditions treatable by an AMPA receptor modulator.

Convenient Approach to 3,4-Diarylisoxazoles Based on the Suzuki Cross-Coupling Reaction

The Suzuki cross-coupling reaction was found effective for rapid access to a series of 3,4-diarylisoxazoles of pharmacological interest. The efficiency of this approach was demonstrated by the synthesis of the highly potent COX-2-selective inhibitor, 4-(5-methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide (valdecoxib), and its analogues. Thus, the coupling reaction between (3-aryl-5-methyl-4-isoxazolyl)boronic acids, prepared in situ from the corresponding bromides using triisopropyl borate, and aryl bromides containing a 4-sulfonamide or 4-methylsulfonyl group under the standard conditions [Pd(PPh3)4, Na2CO3, EtOH-H2O, reflux] yielded the target 3,4-diarylisoxazoles in good yields.

Process for producing sulfonylureas

There is described a novel process for producing sulfonylureas of formula I STR1 wherein R1 is hydrogen or alkyl, R2 is STR2 E is =N-- or =CH--, R3 is alkyl, alkoxy or halogen, R4 is alkyl, cycloalkyl, alkoxy, halogen, alkoxy-alkyl, halo-alkyl or halo-alkoxy, R5 is hydrogen or alkyl, T is a substituted phenyl group STR3 Y is hydrogen or halogen, X is hydrogen, halogen, alkyl, halo-alkyl, alkenyl, halo-alkenyl, alkynyl, alkoxy, halo-alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, halo-alkylthio, alkylsulfonyloxy, phenylsulfonyloxy, phenylsulfonyloxy mono- or polysubstituted by alkyl, or is di-alkylsulfamoyl, and A is a bridge member which has 3 or 4 atoms and which contains 1 or 2 hetero atoms, selected from the group consisting of oxygen, sulfur and nitrogen, the said process comprising reacting a silfonamide of the formula II in the presence of a base, with diphenyl carbonate to form a salt of a phenyl carbamate converting this salt into the free phenyl carbamate and reacting this further with an amine. Sulfonylureas are herbicidally effective compounds.