491876-52-9Relevant academic research and scientific papers
Novel nucleotide triphosphates as potent P2Y2 agonists with enhanced stability over UTP
Davenport, Richard J.,Diaz, Paloma,Galvin, Frances C.A.,Lloyd, Steve,Mack, Stephen R.,Owens, Ray,Sabin, Verity,Wynn, Joanne
, p. 558 - 561 (2007/10/03)
The synthesis of a series of novel C-linked nucleotide triphosphates is reported. These exhibit excellent agonist potency and selectivity for the P2Y2 receptor with a number of examples having EC50 values below 10 nM. Representative compounds from the N-linked and C-linked series showed enhanced metabolic stability compared with that of the natural ligand UTP.
