4919-40-8

Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 70, p. 317, 1948 DOI: 10.1021/ja01181a097

InChI:InChI=1/C9H11NO2/c1-5-3-7(9(11)12)4-6(2)8(5)10/h3-4H,10H2,1-2H3,(H,11,12)

Upstream product

• 3095-38-3 3,5-dimethyl-4-nitrobenzoic acid 
• 80238-12-6 2,6-dimethyl-terephthalic acid 
• 67-66-3 chloroform 
• 7664-93-9 sulfuric acid 
• 108-67-8 1,3,5-trimethyl-benzene 

Downstream Products

• 3095-48-5 4-amino-3,5-dimethyl-benzoic acid methyl ester 
• 4919-37-3 3,5-dimethyl-4-hydroxybenzoic acid 
• 87-62-7 2,6-dimethylaniline 
• 576-26-1 2.6-dimethylphenol 
• 1048677-11-7 4-iodo-3,5-dimethylbenzoic acid 
• 1616605-03-8 C₁₆H₁₇NO₅S 
• 1608997-40-5 (E)-5-ammonio-3-(2-(4-carboxy-2,6-dimethylphenyl)hydrazono)-4-oxo-3,4-dihydronaphthalene-2,7-disulfonate 
• 1103906-41-7 N,N'-di-(2,6-dimethyl-4-benzoic acid)-1,4,5,8-naphthalenetetracarboxylic acid diimide 

Relevant academic research and scientific papers

Photosensitive chiral self-assembling materials: Significant effects of small lateral substituents

Novel azobenzene-based photosensitive mesogens with lactate chiral units were synthesized. In order to modify the rate of the thermal Z-E isomerization of these compounds, small lateral substituents were introduced into their core in the proximity of the azo group. The influence of lateral substitution on the kinetics of the Z-E isomerization, mesomorphic behaviour, and UV-Vis absorption spectra was studied. It was found that the position of the substituents in the azobenzene core significantly affects the rate of their thermal isomerization. The stability of Z-isomers of several studied compounds is comparable to that of compounds with complex molecular structures designed for optical data storage. Although lateral substitution influences the breadth/length ratio of the core, liquid-crystalline properties of the studied materials have been preserved.

Design, synthesis and biological evaluation of small-azo-dyes as potent Vesicular Glutamate Transporters inhibitors

Vesicular Glutamate Transporters (VGLUTs) allow the loading of presynapic glutamate vesicles and thus play a critical role in glutamatergic synaptic transmission. VGLUTs have proved to be involved in several major neuropathologies and directly correlated to clinical dementia in Alzheimer and Parkinson's disease. Accordingly VGLUT represent a key biological target or biomarker for neuropathology treatment or diagnostic. Yet, despite the pivotal role of VGLUTs, their pharmacology appears quite limited. Known competitive inhibitors are restricted to some dyes as Trypan Blue (TB) and glutamate mimics. This lack of pharmacological tools has heavily hampered VGLUT investigations. Here we report a rapid access to small molecules that combine benefits of TB and dicarboxylic quinolines (DCQs). Their ability to block vesicular glutamate uptake was evaluated. Several compounds displayed low micromolar inhibitory potency when size related compounds are thirty to forty times less potent (i.e. DCQ). We then confirmed the VGLUT selectivity by measuring the effect of the series on vesicular monoamine transport and on metabotropic glutamate receptor activity. These inhibitors are synthesized in only two steps and count among the best pharmacological tools for VGLUTs studies.

AMINO ACID COMPOUNDS

[Problem] To provide novel compounds that are S1P1 receptor agonists and exhibit an immunosuppressive activities by inducing lymphocyte sequestration in secondary lymphoid tissues. In addition, to provide a pharmaceutical agent which comprises the compounds as an effective component, in particular to provide a therapeutic and/or prophylactic agent for an autoimmune disease and the like. [Solving Means] Amino acid compounds that are represented by the following Formula (1) are provided