4921-85-1

Usage

Compound class

Thioureas

Common uses

Catalyst for the synthesis of various organic compounds, reagent in chemical research

Physical appearance

White crystalline solid

Molar mass

342.41 g/mol

Versatility

Potential applications in pharmaceuticals, agrochemicals, and materials science

Biological properties

Antimicrobial and anticancer properties

Potential use

Promising candidate for drug development

Precautions

Potential health hazards and environmental impact when handling BNTU

InChI:InChI=1/C18H14N2OS/c21-17(14-7-2-1-3-8-14)20-18(22)19-16-11-10-13-6-4-5-9-15(13)12-16/h1-12H,(H2,19,20,21,22)

Upstream product

• 91-59-8 naphthalen-2-ylamine 
• 532-55-8 Benzoyl isothiocyanate 
• 98-88-4 benzoyl chloride 

Downstream Products

• 3394-04-5 naphthalen-2-yl-thiourea 

Relevant academic research and scientific papers

Synergism of fused bicyclic 2-aminothiazolyl compounds with polymyxin B against: Klebsiella pneumoniae

A series of fused bicyclic 2-aminothiazolyl compounds were synthesized and evaluated for their synergistic effects with polymyxin B (PB) against Klebsiella pneumoniae (SIPI-KPN-1712). Some of the synthesized compounds exhibited synergistic activity. When 4 μg ml-1 compound B1 was combined with PB, it showed potent antibacterial activity, achieving 64-fold reduction of the MIC of PB. Furthermore, compound B1 showed prominent synergistic efficacy in both concentration gradient and time-kill curves in vitro. In addition, B1 combined with PB also exhibited synergistic and partial synergistic effect against E. coli (ATCC25922 and its clinical isolates), Acinetobacter baumannii (ATCC19606 and its clinical isolates), and Pseudomonas aeruginosa (Pae-1399).

Microwave Promoted Efficient Synthesis of N-Aryl-N′-aroyl Thioureas under Solvent-Free and Phase Transfer Catalysis Conditions

A simple, rapid and efficient method for the synthesis of N-aryl-N′-aroyl thioureas under phase transfer catalysis, microwave irradiation and solvent-free conditions is reported.

A mild and efficient synthesis of N-aryl-N′-aroyl thioureas under phase transfer catalysis and solvent-free conditions

A series of N-aryl-N′-aroyl thioureas 3a-m were synthesized in high yields (80.0-98.1%) by an environmentally benign, simple and efficient method under phase transfer catalysis and solvent-free conditions.

Thermal Decomposition of Aromatic Thioureas

Thermal decomposition of aromatic and heteroaromatic thioureas in boiling chlorobenzene is a first-order reaction.The reaction involves intramolecular hydrogen transfer followed by a cleavage of the C - N bond which is the rate-limiting step.The rate constants of decomposition have been determined and correlated with quantum-chemical reactivity indices. - Key words: Thioureas, Isothiocyanates, Thermal Decomposition, Side-Chain Elimination, Kinetics