492471-13-3

Upstream product

• 492471-01-9 3-(4-bromo-phenyl)-2-(3,4-difluoro-phenyl)-7-methoxy-benzo[b]thiophene 
• 492470-96-9 1-(4-bromo-phenyl)-2-(3,4-difluoro-phenyl)-2-(2-methoxy-phenylsulfanyl)-ethanone 
• 7217-59-6 2-Methoxybenzenethiol 
• 75-36-5 acetyl chloride 
• 405201-31-2 3-(4-bromo-phenyl)-2-(3,4-difluoro-phenyl)-benzo[b]thiophen-7-ol 

Relevant academic research and scientific papers

A facile synthesis of 7,8-di aryl coumarino and flavano benzo-thiophenes

The key step for the synthesis of 7-hydroxy 2,3-diarylsubstituted benzothiophenes 5a-f, by starting from substituted 2-aryl-2-((2-methoxy phenyl)thio)acetophenones 3a-f as an intermediate, consists of a Friedel-Crafts cyclization followed by demethylation by Lewis acids like BF3OEt2 and AlCl3 in DCM.