4926-56-1

Upstream product

• 108-00-9 N,N-dimethylethylenediamine 
• 89-61-2 2,5-dichloronitrobenzene 
• 100-36-7 N,N-diethylethylenediamine 

Downstream Products

• 56756-63-9 1-Chlor-3-amino-4-(2-dimethylamino-aethylamino)-benzol 
• 1415488-80-0 2-[5-chloro-2-(2-methoxyphenyl)-1H-benzo[d]imidazol-1-yl]-N,N-diethylethanamine 
• 1415488-81-1 2-[5-chloro-2-(5-methylthiophen-2-yl)-1H-benzo[d]imidazol-1-yl]-N,N-diethylethanamine 
• 126568-04-5 7-cloro-4-fenil-1-<(dimetilammino)etil>-1,3-diidro-2H-1,5-benzodiazepin-2-one 

Relevant academic research and scientific papers

Synthesis and anti-inflammatory evaluation of novel benzimidazole and imidazopyridine derivatives

Sepsis, an acute inflammatory disease, remains the most common cause of death in intensive care units. A series of benzimidazole and imidazopyridine derivatives were synthesized and screened for anti-inflammatory activities, and the imidazopyridine series showed excellent inhibition of the expression of inflammatory cytokines in LPS-stimulated macrophages. Compounds X10, X12, X13, X14, and X15 inhibited TNF-α and IL-6 release in a dose-dependent manner, and X12 showed no cytotoxicity in hepatic cells. Furthermore, X12 exhibited a significant protection against LPS-induced septic death in mouse models. Together, these data present a series of new imidazopyridines with potential therapeutic effects in acute inflammatory diseases.

Riminophenazine derivatives as potential antituberculosis agents: Synthesis, biological, and electrochemical evaluations

A series of novel riminophenazine derivatives, having ionizable alkyl substituents at N-5 and a variety of substituents on the C-3 imino nitrogen, at C-8 and on the pendant aryl group, have been designed and synthesized. Preliminary investigations into th