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493038-87-2

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493038-87-2 Usage

General Description

4-Pyridin-2-yl-2H-pyrazol-3-ylamine, also known as 4-pyridin-2-yl-2H-pyrazol-3-amine, is a chemical compound with the molecular formula C10H9N5. It is a pyrazole derivative with a pyridine ring attached to the 2-position of the pyrazole ring. 4-Pyridin-2-yl-2H-pyrazol-3-ylamine is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has also been studied for its potential biological activities, including anti-inflammatory and anticancer properties. Additionally, it has been used in the development of novel materials for various applications. Overall, 4-pyridin-2-yl-2H-pyrazol-3-amine is a versatile compound with potential applications in the fields of medicine, agriculture, and materials science.

Check Digit Verification of cas no

The CAS Registry Mumber 493038-87-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,9,3,0,3 and 8 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 493038-87:
(8*4)+(7*9)+(6*3)+(5*0)+(4*3)+(3*8)+(2*8)+(1*7)=172
172 % 10 = 2
So 493038-87-2 is a valid CAS Registry Number.
InChI:InChI=1/C8H8N4/c9-8-6(5-11-12-8)7-3-1-2-4-10-7/h1-5H,(H3,9,11,12)

493038-87-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(2-Pyridinyl)-1H-pyrazol-5-amine

1.2 Other means of identification

Product number -
Other names 2,4'-Bipyridine,1',2',3',6'-tetrahydro

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:493038-87-2 SDS

493038-87-2Relevant articles and documents

Synthesis and benzodiazepine receptor affinity of pyrazolo[1,5-a]pyrimidine derivatives. 3. New 6-(3-thienyl) series as α1 selective ligands

Selleri, Silvia,Bruni, Fabrizio,Costagli, Camilla,Costanzo, Annarella,Guerrini, Gabriella,Ciciani, Giovanna,Gratteri, Paola,Bonaccini, Claudia,Malmberg Aiello, Petra,Besnard, Fran?ois,Renard, Stephane,Costa, Barbara,Martini, Claudia

, p. 310 - 313 (2003)

New 3-aryl-6-(3-thienyl)pyrazolo[1,5-a]pyrimidin-7-ones (2a-j) are synthesized and evaluated in vitro on Bz/GABAA receptors and on recombinant benzodiazepine receptors (αxβ2/3γ2; x = 1-3, 5) expressed in HEK293 cells. SAR studies on the new com

A oxazolidinone antibacterial compound of intermediate and its preparation method

-

Paragraph 0072-0074, (2017/11/16)

The invention provides a new intermediate compound 2-(1-(2-fluoro-4-nitrophenyl)-1H-pyrazole-3(5)-amino-4-yl)pyridine represented by formula 4 in the production process of a compound (S)-N-{[3-(3-fluoro-4-(4-(2-pyridyl)pyrazolyl)phenyl)-2-oxazolidine-5-yl]methyl}acetamide, and a preparation method thereof. The new intermediate guarantees the abundant source of synthesis raw materials, reduces the cost of the raw materials, omits a complicated column chromatography purifying technology, makes the operation simple, and makes the amplified production of the target compound possible.

Exploratory process development and kilogram-scale synthesis of a novel oxazolidinone antibacterial candidate

Yang, Tao,Chen, Jia-Xiang,Fu, Yiwei,Chen, Kaixiao,He, Jinyun,Ye, Weiwei,Sang, Zitai,Luo, Youfu

, p. 511 - 519 (2014/05/06)

A concise, environmentally benign, and cost-effective route was developed for the large-scale preparation of 1, a novel oxazolidinone antibacterial candidate. The key intermediate 2-(1-(2-fluoro-4-nitrophenyl)-1H-pyrazol-4-yl) pyridine 7 was prepared with high purity by mild deamination of the regioisomeric mixture 21. The mixture was prepared from a nucleophilic SNAr reaction by selective C-N coupling of the secondary amine functionality of 4-(pyridin-2-yl)-1H-pyrazol-3-amine 14 with 1,2-difluoro-4-nitrobenzene 10 in optimized conditions with the primary amine group remaining intact. The gaseous nitrogen release rate and reaction mixture temperature of the deamination step can be well controlled by altering the feeding manner, thereby providing safety guarantees. The optimized synthetic strategy of 1 with an overall yield of 27.6%, including seven sequential transformations by only five solid-liquid isolations, significantly improved the product separation workup. The strategy bypassed time-consuming and laborious procedures for any intermediate involved as well as for the final API. This study presents a process enabling the rapid delivery of a multikilogram quantity of API with high purity.

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