4931-82-2Relevant academic research and scientific papers
Di-μ-hydroxy-bis(N,N,N′,N′-tetramethylenediamine)-copper(II) chloride [Cu(OH)·TMEDA]2Cl2: An efficient, practical catalyst for benzylation and allylation of amides
Kumaraswamy,Pitchaiah,Ramakrishna,Ramakrishna,Sadaiah
, p. 2013 - 2015 (2007/10/03)
An efficient protocol for the benzylation or allylation of amides using the corresponding benzyl or allyl chlorides as electrophiles under basic conditions with commercially available 5 mol % of [Cu(OH)TMEDA]2Cl2 as catalyst was developed. Under these conditions, unprotected amino acids were benzylated without any racemization.
Protection by pyroglutamic acid and some of its newly synthesized derivatives against glutamate-induced seizures in mice
Beani,Bianchi,Baraldi,Manfredini,Pollini
, p. 1187 - 1191 (2007/10/02)
The protection by pyroglutamic acid (CAS 98-79-3) and derivatives Ia-i (injected i.p.) against glutamate- and NMDA (N-methyl-D-aspartate) (i.c.v.) induced seizures in mice has been studied in comparison with known antiepileptics and antagonists of excitatory aminoacids. The potency of pyroglutamic acid and some derivatives (Id,f,g,h) against glutamate-induced convulsions was similar to that shown by glutamic acid diethylester and by valproic acid. Interestingly, pyroglutamic acid did not affect NMDA-induced convulsions which were well antagonized by both 2-amino-5-phosphono valeric acid and by diazepam. Thus, pyroglutamic acid may represent the starting for synthesis of excitatory aminoacid antagonists acting at non NMDA receptors.
CARBONYL RADICAL CYCLIZATIONS: PREPARATION OF SOME HETEROCYCLIC KETONES
Crich, David,Eustace, K. Angeline,Ritchie, Timothy J.
, p. 67 - 70 (2007/10/02)
It has been possible to synthesize 3-methylchromanone, 3-methylthiochromanone and 2,3-dihydro-3-methylquinolin-4-one from salicylic acid, thiosalicylic acid and anthranilic acid respectively by carbonyl radical cyclizations.
