Welcome to LookChem.com Sign In|Join Free

CAS

  • or

4933-77-1

Post Buying Request

4933-77-1 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

4933-77-1 Usage

Purpose

Used in organic synthesis and carbohydrate chemistry

Derivative of

D-galactose

Function

Commonly used as a protecting group for hydroxyl groups in carbohydrates

Physical appearance

White to off-white powder

Molecular weight

288.34 g/mol

Melting point

Around 140-143°C

Solubility

Soluble in various organic solvents such as acetone and ethyl acetate

Applications

Important in the development of new drugs, synthesis of complex natural products, and pharmaceuticals

Check Digit Verification of cas no

The CAS Registry Mumber 4933-77-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,9,3 and 3 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 4933-77:
(6*4)+(5*9)+(4*3)+(3*3)+(2*7)+(1*7)=111
111 % 10 = 1
So 4933-77-1 is a valid CAS Registry Number.

4933-77-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name (2,2,7,7-Tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d] pyran-5-yl)methanol (non-preferred name)

1.2 Other means of identification

Product number -
Other names 2,2,7,7-tetramethyl-(3aR,5S,5aR,8aR,8bR)-tetrahydrodi[1,3]dioxolo[5,4-b,5,4-d]pyran-5-carbaldehyde

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:4933-77-1 SDS

4933-77-1Relevant articles and documents

Synthesis and Conformational Analysis of (6R)--1,2:3,4-Di-O-isopropylidene-α-D-galactopyranose. NMR and Molecular Modeling Studies

Midland, M. Mark,Asirwatham, Gitanjali,Cheng, John C.,Miller, Jennifer A.,Morell, Luis A.

, p. 4438 - 4442 (1994)

The conformation preferences of 1,2:3,4-di-O-isopropylidene-α-D-galactopyranose have been determined using NMR and molecular modeling (conformational searching) techniques.The pyranose ring assumes a skew-boat conformation.Coupling constants for the C6 side chain and hydroxyl proton indicate that the predominant conformation places the oxygen anti to C4 (gt conformation) with the hydroxyl hydrogen aligned toward the pyranose oxygen in deuteriochloroform.A similar orientation of the C5-C6 bond was observed in water and toluene.In DMSO the C6 oxygen is anti to the pyranose oxygen (tg conformation) with the hydroxyl hydrogen anti to C5.A similar orientation of the C5-C6 bond was observed in methanol.

Synthesis and conformational properties of methyl 6,6-di-C-methyl-beta-D-galactopyranoside. Probes for the combining sites of D-galactosyl-binding proteins.

Lough,Hindsgaul,Lemieux

, p. 43 - 53 (1983)

The binding of D-galactopyranosyl groups by lectins and antibodies can involve the 5-hydroxymethyl group. In order to examine the nature of these binding reactions, it was of interest to synthesize 6,6-di-C-methyl-D-galactose which was found to exist, like D-galactose, extensively in the pyranose forms. 2,3,4,6-Tetra-O-acetyl-7-deoxy-6-C-methyl-alpha-D-galacto-heptopyranosyl bromide was prepared under standard conditions and converted into methyl 6,6-di-C methyl-beta-D-galactopyranoside (6). Evidence based on 13C-n.m.r. studies indicates that the favored conformer of 6 has O-4 and O-6 in syn-axial-like relationship. General comments are presented on the nature of the binding of oligosaccharides by proteins.

The synthesis and conformational properties of the diastereoisomeric βDGal(1-4)βDGlcNAc(1-6)6-C-CH3-D-Gal trisaccharides

Lemieux, Raymond U.,Wong, Ting C.,Thogersen, Henning

, p. 81 - 86 (1982)

The trisaccharide βDGal(1->4)βDGlcNAc(1->6)DGal was known to be bound strongly by the so-called anti-I Ma monoclonal antibody.In order to help assess the conformation about the 1->6 glycosidic linkage that is accepted by the antibody combining site, the conformationally well-defined βDGal(1->4)βDGlcNAc(1->6) derivatives of 7-deoxy-L-glycero-D-galacto-heptopyranose and 7-deoxy-D-glycero-D-galacto-heptopyranose were synthesized.The conformational preferences for these trisaccharides were estabished by 1H nmr spectroscopy and rationalized by computer-assisted molecular modelling.

ANALOGS OF CELL SURFACE CARBOHYDRATES. SYNTHESIS OF D-GALACTOSE DERIVATIVES HAVING AN ETHYNYL, VINYL OR EPOXY RESIDUE AT C-5

Lee, Ho H.,Hodgson, Philip G.,Bernacki, Ralph J.,Korytnyk, Walter,Sharma, Moheswar

, p. 59 - 72 (1988)

Compounds derived from D-galactose having an ethynyl, vinyl, or epoxide residue at C-5, as well as 7,7-dibromo olefinic, isomeric 7,7-gem-bromofluoro olefinic, and 6,6-gem-difluoro derivatives were obtained from 1,2:3,4-di-O-isopropylidene-α-D-galacto-hexodialdo-1,5-pyranose.

Total Synthesis of β- D -ido-Heptopyranosides Related to Capsular Polysaccharides of Campylobacter jejuni HS:4

Zhang, Pengfei,Hevey, Rachel,Ling, Chang-Chun

, p. 9662 - 9674 (2017)

The 6-deoxy-β-d-ido-heptopyranoside related to the capsular polysaccharides of C. jejuni HS:4 is very remarkable, owing to the unique, multifaceted structural features that have been combined into one molecule, which include (1) the rare ido-configuration, (2) the unusual 7-carbon backbone, and (3) the challenging β-(1→2)-cis-anomeric configuration. Two distinct strategies toward the total synthesis of this interesting target are reported. The first involved establishment of the β-d-idopyranosyl configuration from β-d-galactopyranosides, prior to a C-6-homologation extending the d-hexose to the desired 6-deoxy-d-heptose. However, this approach encountered difficulties due to the significantly reduced reactivity of the 6-position of the β-d-idopyranosides, so instead a second strategy was employed, which involved first carrying out a 6-homologation on the less flexible d-galactopyranose, followed by a very successful conversion to the desired β-d-ido-configuration found in the target heptopyranoside (2). This report is the first successful synthesis of the 6-deoxy-β-d-ido-heptopyranoside, which could possess interesting immunological properties.

Multicomponent Approach to Homo-and Hetero-Multivalent Glycomimetics Bearing Rare Monosaccharides

Jakas, Andreja,Jeri?, Ivanka,Vi?njevac, Aleksandar

, p. 3766 - 3787 (2020/03/30)

We applied a multicomponent approach to access a library of densely functionalized homo-and hetero-multivalent glycomimetics comprising aldehyde, amine, and isocyanide components related to isopropylidene-protected d-fructose, l-sorbose, d-galactose, and d-Allose. Passerini products were obtained in very good yields (up to 78%) and high diastereoselectivities (up to 98:2). Three types of products were obtained by the Ugi reaction; along with the "classical" four-component product, α-Acylaminoamides, a three-component α-Aminoamides, and a four-component α-Aminoacylamides were isolated. The presence of multiple pathways is rationalized by the structure of the imidate intermediate, mainly influenced by the amine component.

N-Alkylated C-Glycosyl Amino Acid Derivatives: Synthesis by a One-Pot Four-Component Ugi Reaction

?tefani?, Zoran,Jeri?, Ivanka,Vazdar, Katarina,Vlahovi?ek-Kahlina, Kristina

, p. 838 - 844 (2020/06/02)

C-glycosides represent an important group of naturally occurring glycosylation derivatives but are also efficient mimetics of native O-glycosides. Here, a one-pot four-component methodology is described toward a library of N-alkylated C-glycosyl amino acid derivatives comprising seven different isopropylidene-protected carbohydrate units. The applied methodology tolerates different amines and isocyanides and provides access to Ugi products in yields up to 85 %. X-ray analysis of selected products bearing three different carbohydrate motifs and comparison of their crystal structures with similar ones deposited in Cambridge Crystallographic Database revealed that four structures adopt different conformations, mostly not typical for peptide structures. This property opens the possibility to exploit here described N-alkylated C-glycosyl amino acid derivatives as templates to access different biotic and abiotic secondary structures.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 4933-77-1