4945-29-3

Usage

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 25, p. 819, 1988 DOI: 10.1002/jhet.5570250323

Upstream product

• 55908-34-4 1-Quinolin-4-yl-ethanol 
• 117125-17-4 4-(1-chloro-ethyl)-quinoline 
• 81124-52-9 (E)-3-(quinolin-4-yl)acrylic acid 
• 5632-21-3 4-(oxiran-2-yl)quinoline 
• 67-64-1 acetone 
• 7732-18-5 water 
• 35651-58-2 1-(4-quinolyl)ethyl acetate 
• 18424-76-5 dimethyl malonate sodium salt 
• 69976-09-6 4-quinolinyl-2-propenoic acid methyl ester 
• 4363-93-3 quinoline-4-carboxaldehyde 
• 2065-66-9 methyl-triphenylphosphonium iodide 
• 117125-19-6 methyl-4-(1-hydroxyethyl)quinoline xanthate 

Downstream Products

• 64-18-6 formic acid 
• 486-74-8 4-quinolinic acid 
• 1430235-30-5 C₂₃H₂₁NSi 
• 1430235-54-3 C₂₃H₁₉NSi 

Relevant academic research and scientific papers

Reactivity of quinoline- and isoquinoline-based heteroaromatic substrates in palladium(0)-catalyzed benzylic nucleophilic substitution

(Formula presented) Quinolylmethyl, 1-(isoquinolyl)ethyl, and 1-(quinolyl)ethyl acetates reacted with dimethylmalonate anion in the presence of a Pd(0) catalyst to give products of nucleophilic substitution and/or byproducts, depending upon the substitution pattern. The observed side reactions were reduction in the case of primary acetates and elimination or elimination/Michael-type addition sequence for secondary substrates.

Method for assaying the sod activity by using a self-oxidizable compound necessary for its implementation, self-oxidizable compounds and preparation thereof

The method for assaying the SOD (super oxide dismutase) activity in liquid medium is based on the activation of self-oxidization, by SOD activity, of a reactive agent having the general formula (I) wherein either n is 1 or 2, R1 is --OR4 or --NR5 R6 ; R2 is H, --OR4, alkyl (1-6C), --CH2 -- or --CH2 --CH2 --, to form a ring by binding to the phenyl substituent, at meta with respect to R1 ; and R3 is H, alkyl (1-6C) or --OR4 (if R2 is different from --OR4); with R4 being H or alkyl (1-6C); R5 being H, alkyl (1-6C), --CH2 COOH, --C6 H5 COOH or --C6 H5 SO3 H; and R6 is H, alkyl (1-6C) or --CH2 COOH; or n is 1, R1 is --OR4, R2 is --CH2 --O--, in order to form a ring by bonding of O with the phenyl substituent, at meta with respect to R1 ; and R3 is H or --OR4. Application to assaying the SOD activity in a sample, specially a biological sample, particularly by a single measurement and one calibrating curve.

Synthesis of 4-Vinylquinoline: Pyrolytic Rearrangement of the 4-(1-Hydroxyethyl)quinoline and Related Derivatives

The synthesis of 4-vinylquinoline has been carried out by means of the Wittig reaction between 4-quinolinecarbaldehyde and the methyl triphenylphosphonium ylide in dimethyl sulphoxide in good yield.Dehydration of the 4-(1-hydroxyethyl)quinoline and their xanthate derivative, give equimolar amounts of 4-ethylquinoline and 4-acetylquinoline while small amounts of 4-vinylquinoline were found.Dehydrochlorination of 4-(1-chloroethyl)quinoline in ethanol-sodium hydroxide provides 4-ethyl-3-ethoxyquinoline in good yield, but 4-vinylquinoline is a minor reaction product.

A NOVEL APPROACH TO FUNCTIONALIZATION OF AZINES. OXIRANYL AND THIIRANYL DERIVATIVES OF PYRIDINE, QUINOLINE AND ISOQUINOLINE

Convenient methods for synthesis of the oxiranyl and thiiranyl derivatives of pyridine, quinoline and isoquinoline have been elaborated.Oxiranes have been synthesized from corresponding aldehydes with dimethylsulfonium methylide in anhydrous medium.Exchange of the oxygen atom in the oxirane ring on sulfur with potassium thiocyanate gave thiiranylazines.