494784-12-2

Upstream product

• 494784-01-9 (S)-1-(2,3-O-isopropylidene-2,3-dihydroxypropyl)-3-benzoyluracil 
• 55559-60-9 (S)-1-(2,3-O-isopropylidene-2,3-dihydroxypropyl)uracil 
• 66-22-8 uracil 
• 834906-31-9 (S)-glycidyl 4,4’-dimethoxytrityl ether 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 55559-58-5 (S)-1-(2,3-dihydroxypropyl)uracil 

Relevant academic research and scientific papers

Synthesis of glycol nucleic acids

Starting from glycidol, the synthesis of dimethoxytritylated glycol nucleoside phosphoramidites of adenine (A), thymine (T), uracil (U), guanine (G), and cytosine (C) is reported. These phosphoramidites are the building blocks for the automated solid phas

Oligonucleotide conjugates based on acyclonucleosides and their use in DNA hybridization assays

Synthesis of two oligonucleotide building blocks based on acyclonucleosides (10, 11) which enable the introduction of several nonluminescent and luminescent lanthanide(III) chelates to the oligonucleotide structure is described. They were used in an instrument-assisted DNA synthesis in a standard manner. A modified deprotection procedure was used to ensure metal complexation. Also the applicability of these oligonucleotide conjugates to DNA hybridization assays is demonstrated.