494833-75-9

Usage

Uses

Used in Pharmaceutical Research:
2-BROMO-4-(N-TERT-BUTYLOXYCARBONYLAMINO)THIOPHENE is used as a building block for the synthesis of pharmaceuticals due to its ability to contribute to the development of biologically active molecules. Its unique structure allows for the creation of compounds with potential therapeutic properties.
Used in Agrochemical Production:
In the agrochemical industry, 2-BROMO-4-(N-TERT-BUTYLOXYCARBONYLAMINO)THIOPHENE is utilized as a starting material for the synthesis of various agrochemicals. Its role in creating active ingredients for pesticides and other agricultural chemicals highlights its importance in this field.
Used in Materials Science:
2-BROMO-4-(N-TERT-BUTYLOXYCARBONYLAMINO)THIOPHENE also finds applications in materials science, where it is employed in the development of new materials with specific properties. Its versatility in chemical reactions enables the creation of materials with tailored characteristics for various applications.
Used in the Synthesis of Heterocyclic Compounds:
Furthermore, 2-BROMO-4-(N-TERT-BUTYLOXYCARBONYLAMINO)THIOPHENE is used as a starting material in the synthesis of heterocyclic compounds. These compounds are essential in various chemical and pharmaceutical applications, further expanding the utility of this thiophene derivative.

InChI:InChI=1/C9H12BrNO2S/c1-9(2,3)13-8(12)11-6-4-7(10)14-5-6/h4-5H,1-3H3,(H,11,12)

Upstream product

• 100523-84-0 2-bromothiophene-4-carboxylic acid 
• 75-65-0 tert-butyl alcohol 
• 1373346-87-2 C₅H₂BrNOS 

Relevant academic research and scientific papers

SULFONYLUREA DERIVATIVES AND USES THEREOF

The present disclosure relates to compounds of Formula (I) and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.

1,2,4-TRIAZINE-6-CARBOXAMIDE DERIVATIVE

The present invention provides a compound represented by the following general formula (I) or a salt thereof which has a Syk inhibitory effect (in the formula R1 represents a hydrogen atom or an optionally Ra-substituted C1-C6 alkyl group; A represents a hydrogen atom, an optionally Ra-substituted C1-C8 alkyl group, an optionally Ra-substituted C2-C6 alkenyl group, an optionally Ra-substituted C2-C6 alkynyl group, an optionally Rb-substituted C3-C10 cycloalkyl group, an optionally Rb-substituted C6-C14 aromatic hydrocarbon group, an optionally Rb-substituted 4- to 10-membered unsaturated heterocyclic group, or an optionally Rb-substituted 4-to 10-membered saturated heterocyclic group, or optionally forms a 4- to 10-membered unsaturated heterocyclic ring or a 4- to 10-membered saturated heterocyclic ring together with R1 and the nitrogen atom bonded thereto; R2 represents a hydrogen atom or an optionally Ra-substituted C1-C6 alkyl group; and B represents an optionally Rc-substituted unsaturated heterocyclic group).

Polycyclic aromatics with flanking thiophenes: Tuning energy level and band gap of conjugated polymers for bulk heterojunction photovoltaics

In the pursuit of donor-acceptor low band gap polymers for photovoltaic applications, finding an optimal donor monomer which maximizes the photovoltaic efficiency is a complex synthetic optimization problem. We synthesized three different bithiophenes flanking a center aromatic ring (pyrrole, benzene, or pyridine) as the donor monomers (DTPr, DTBn, and DTPn) with decreasing electron-donating ability. An array of six electrochemically and optically unique polymers were prepared by copolymerizing these three monomers with 2,1,3-benzothiadiazole and with thiophene. The optical, electronic, and photovoltaic properties of these polymers were investigated. Among this series, we found that the HOMO energy level of the polymer is dominated by the most electron-rich ring in the polymer backbone. The optical band gap, conversely, involves the entire polymeric system. Among the three donor monomers investigated, we identified that DTBn-based polymers exhibited the most potential in photovoltaic applications due to their moderately low band gaps and low HOMO energy levels.

THIOPHENE-CARBOXAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE ENZIME IKK-2

The invention relates to thiophene carboxamides of formula (I), wherein A, R1, R2, R3, R4, R5 and X are as defined in the specification, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy.

THIOPHENE CARBOXAMIDES AS INHIBITORS OF THE ENZYME IKK-2

The invention relates to thiophene carboxamides of formula (I) wherein Ar, R1, R2, R3, R4, R5, m and n are as defined in the specification, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy.