2-BROMO-4-(N-TERT-BUTYLOXYCARBONYLAMINO)THIOPHENE

Base Information

• Chemical Name: 2-BROMO-4-(N-TERT-BUTYLOXYCARBONYLAMINO)THIOPHENE
• CAS No.: 494833-75-9
• Molecular Formula: C9H12 Br N O2 S
• Molecular Weight: 278.17
• Hs Code.: 2934999090
• Mol file: 494833-75-9.mol

Synonyms:2-Bromo-4-((tert-butyloxycarbonyl)amino)thiophene;2-Bromo-4-(N-tert-butyloxycarbonylamino)thiophene

Chemical Property of 2-BROMO-4-(N-TERT-BUTYLOXYCARBONYLAMINO)THIOPHENE

Chemical Property:

• Vapor Pressure: 0.005mmHg at 25°C
• Melting Point: 88-91 °C(Solv: cyclohexane (110-82-7))
• Boiling Point: 276.78oC at 760 mmHg
• PKA: 13.03±0.70(Predicted)
• Flash Point: 121.192oC
• PSA: 66.57000
• Density: 1.511g/cm3
• LogP: 3.93060
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

2-Bromo-4-(N-tert-Butyloxycarbonylamino)thiophene 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMO-4-(N-TERT-BUTYLOXYCARBONYLAMINO)THIOPHENE

There total 2 articles about 2-BROMO-4-(N-TERT-BUTYLOXYCARBONYLAMINO)THIOPHENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

2-bromothiophene-4-carboxylic acid (100523-84-0) + tert-butyl alcohol (75-65-0) → tert‐butyl N‐(5‐bromothiophen‐3‐yl)carbamate (494833-75-9)

Guidance literature:

With diphenyl phosphoryl azide; N-ethyl-N,N-diisopropylamine; at 85 ℃; for 12h; Inert atmosphere;

Reference yield:

C5H2BrNOS (1373346-87-2) + tert-butyl alcohol (75-65-0) → tert‐butyl N‐(5‐bromothiophen‐3‐yl)carbamate (494833-75-9)

Guidance literature:

In toluene; at 80 ℃; for 16h; Inert atmosphere;

DOI:10.1021/ma902164q

Reference yield: 25.0%

tert‐butyl N‐(5‐bromothiophen‐3‐yl)carbamate (494833-75-9) + dihydroxy-methyl-borane (13061-96-6) → tert-butyl (5-methylthiophen-3-yl)carbamate

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; cesium fluoride; In 1,4-dioxane; at 90 ℃; for 12h;

upstream raw materials:

2-bromothiophene-4-carboxylic acid

tert-butyl alcohol

C₅H₂BrNOS

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