494836-49-6

Upstream product

• 147291-50-7 benzyl ((4-(aminomethyl)phenyl)(imino)methyl)carbamate 
• 494836-36-1 (1R,3S,6S,8S,8aS)-6-Azido-6-benzyl-1-ethyl-8-methoxy-5-oxo-octahydro-indolizine-3-carboxylic acid 
• 138629-30-8 (S)-tert-butyl 2-((tert-butyldiphenylsilyloxy)methyl)-5-oxopyrrolidine-1-carboxylate 
• 494836-35-0 (1R,3S,6S,8S,8aS)-6-Azido-6-benzyl-3-(tert-butyl-diphenyl-silanyloxymethyl)-1-ethyl-8-methoxy-hexahydro-indolizin-5-one 
• 494836-26-9 (2S,3R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-ethyl-2-((S)-5-oxo-tetrahydro-furan-2-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 494836-47-4 (1R,3S,6S,8S,8aS)-6-Benzyl-3-(tert-butyl-diphenyl-silanyloxymethyl)-1-ethyl-8-methoxy-hexahydro-indolizin-5-one 
• 494836-41-8 (1R,3S,8S,8aS)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-1-ethyl-8-hydroxy-hexahydro-indolizin-5-one 
• 494836-39-4 2-acetoxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-3-ethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 494836-27-0 (1R,3S,8S,8aS)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-1-ethyl-8-methoxy-hexahydro-indolizin-5-one 
• 494836-25-8 5-(tert-butyl-diphenyl-silanyloxymethyl)-3-ethyl-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 494836-48-5 (1R,3S,6S,8S,8aS)-6-Azido-6-benzyl-1-ethyl-3-hydroxymethyl-8-methoxy-hexahydro-indolizin-5-one 

Relevant academic research and scientific papers

Targeting thrombin and factor VIIa: Design, synthesis, and inhibitory activity of functionally relevant indolizidinones

Guided by molecular modeling, docking experiments, and available X-ray crystal structure data on the serine protease Factor VIIa and thrombin, a series of indolizidinone derivatives was designed and synthesized having diverse functionality at the P1, P2, and P3 sites.