494841-87-1

Upstream product

• 494841-85-9 tert-butyl (3S)-3-(2-chloro-3-pyridinyl)-3-(2,3-dihydro-1-benzofuran-6-yl)propanoate 
• 494841-80-4 2-chloro-3-{(E)-[2-(4S,5S)-4-methoxymethyl-5-(4-methylthiophenyl)-4,5-dihydro-1,3-oxazol-2-yl]vinyl}pyridine 
• 494841-83-7 (3S)-3-(2-chloro-3-pyridinyl)-3-(2,3-dihydro-1-benzofuran-6-yl)propanoic acid 
• 36404-88-3 2-chloro-3-carbaldehydepyridine 
• 6602-54-6 2-chloro-3-pyridinecarbonitrile 
• 494841-86-0 tert-butyl (3S)-3-(2-methoxycarbonyl-3-pyridinyl)-3-(2,3-dihydro-1-benzofuran-6-yl)propanoate 

Relevant academic research and scientific papers

Asymmetric synthesis of a selective endothelin a receptor antagonist

An asymmetric synthesis of a selective endothelin A receptor antagonist 1b is described. Asymmetric conjugate addition of aryllithium derived from 18 to the chiral oxazoline 17 followed by hydrolysis afforded 15 in 96% ee via purification as (S)-(-)-1-phe