4953-59-7

Upstream product

• 56676-49-4 2-mercapto-3-(o-methoxyphenyl)-4-thiazolidone 
• 1075256-86-8 3-(2-methoxyphenyl)-5-(2-oxo-2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one 
• 67-56-1 methanol 

Downstream Products

• 252004-95-8 4-imino-1-(2-methoxy-phenyl)-3-phenyl-5-thioxo-imidazolidin-2-one 
• 116709-10-5 1-(3-chlorophenyl)-3-(2-methoxyphenyl)-5-imino-2,4-imidazolidinedithione 

Relevant academic research and scientific papers

Studies on 4-thiazolidinones: Scope of the reactions of 3-aryl-2-thioxo-1,3-thiazolidin-4-ones with cyanide and cyanate ions

Treatment of 3-aryl-2-thioxo-1,3-thiazolidin-4-ones 1 with CN- and NCO- effected the ring cleavage providing [(cyanocarbonothioyl) amino]benzenes 4 and arylisothiocyanates 5, respectively. Similar treatment of 5-(2-aryl-2-oxoethyl) derivatives 2 afforded 2,4-bis(2-aryl-2-oxoethylidene) cyclobutane-1,3-diones 6 along with each of the preceding products. Treatment of the respective (E,Z)-5-(2-aryl-2-oxoethylidene) analogues 3b and 3c with CN- gave 4b and 4c and 2-(arylcarbonyl)-2-methoxy-4- oxopentanedinitriles 7b and 7c, in addition to 3,6-bis[2-(4-chlorophenyl)-1- methoxy-2-oxoethylidene]-1,4-dithiane-2,5-dione 8c, which has been generated from 3c. Reactions of 3c or 3d with NCO- provided 5c or 5d, together with 8c or 8d as pure isomers. In the formation of the MeO products 7 and 8, the solvent (MeOH) has participated. Structures of these products are based on microanalytical and spectroscopic data. Rationalizations for the above transformations are given.