56676-49-4

Basic information

• Product Name: 3-(2-methoxyphenyl)-2-sulfanylidene-thiazolidin-4-one
• Synonyms: 3-(2-methoxyphenyl)-2-sulfanylidene-thiazolidin-4-one;3-(2-Methoxyphenyl)-2-thioxo-4-thiazolidinone, 95%;3-(2-METHOXYPHENYL)-RHODANINE;3-(2-Methoxyphenyl)-2-thioxothiazolidin-4-one
• CAS NO: 56676-49-4
• Molecular Formula: C₁₀H₉NO₂S₂
• Molecular Weight: 239.32
• Mol File: 56676-49-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 363.6°Cat760mmHg
• Flash Point: 173.7°C
• Appearance: /
• Density: 1.44g/cm³
• Vapor Pressure: 1.79E-05mmHg at 25°C
• Refractive Index: 1.699
• CAS DataBase Reference: 3-(2-methoxyphenyl)-2-sulfanylidene-thiazolidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-methoxyphenyl)-2-sulfanylidene-thiazolidin-4-one(56676-49-4)
• EPA Substance Registry System: 3-(2-methoxyphenyl)-2-sulfanylidene-thiazolidin-4-one(56676-49-4)

Safety Data

• Hazardous Substances Data: 56676-49-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H9NO2S2/c1-13-8-5-3-2-4-7(8)11-9(12)6-15-10(11)14/h2-5H,6H2,1H3

Upstream product

• 2365-48-2 Methyl thioglycolate 
• 3288-04-8 1-isothiocyanato-2-methoxybenzene 
• 75-15-0 carbon disulfide 
• 3926-62-3 sodium monochloroacetic acid 
• 90-04-0 2-methoxy-phenylamine 

Downstream Products

• 130189-41-2 3-(2-Methoxy-phenyl)-5-piperidin-1-ylmethyl-2-thioxo-thiazolidin-4-one 
• 75003-59-7 3-(2-Methoxy-phenyl)-5-pyridin-2-yl-2-thioxo-thiazolidin-4-one 
• 75003-49-5 3-(2-Methoxy-phenyl)-5-quinolin-2-yl-2-thioxo-thiazolidin-4-one 
• 3288-04-8 1-isothiocyanato-2-methoxybenzene 
• 4953-59-7 1-[(cyanocarbonothioyl)amino]-2-methoxybenzene 
• 130189-21-8 5-Diethylaminomethyl-3-(2-methoxy-phenyl)-2-thioxo-thiazolidin-4-one 
• 130189-31-0 3-(2-Methoxy-phenyl)-5-morpholin-4-ylmethyl-2-thioxo-thiazolidin-4-one 
• 18331-97-0 3-(2-methoxy-phenyl)-5-(2-oxo-acenaphthen-1-ylidene)-2-thioxo-thiazolidin-4-one 
• 18332-00-8 5-(6-iodo-2-oxo-acenaphthen-1-ylidene)-3-(2-methoxy-phenyl)-2-thioxo-thiazolidin-4-one 
• 18332-03-1 5-(5,6-diiodo-2-oxo-acenaphthen-1-ylidene)-3-(2-methoxy-phenyl)-2-thioxo-thiazolidin-4-one 
• 18332-02-0 5-(5,6-dibromo-2-oxo-acenaphthen-1-ylidene)-3-(2-methoxy-phenyl)-2-thioxo-thiazolidin-4-one 
• 18332-01-9 5-(5,6-dichloro-2-oxo-acenaphthen-1-ylidene)-3-(2-methoxy-phenyl)-2-thioxo-thiazolidin-4-one 
• 20329-52-6 5-(6-bromo-2-oxo-acenaphthen-1-ylidene)-3-(2-methoxy-phenyl)-2-thioxo-thiazolidin-4-one 
• 18331-99-2 5-(6-chloro-2-oxo-acenaphthen-1-ylidene)-3-(2-methoxy-phenyl)-2-thioxo-thiazolidin-4-one 

Relevant articles and documents

Design, synthesis and biological evaluation of imidazolidine-2,4-dione and 2-thioxothiazolidin-4-one derivatives as lymphoid-specific tyrosine phosphatase inhibitors

Lymphoid-specific tyrosine phosphatase (LYP), which exclusively exists in immune cells and down-regulates T cell receptor signaling (TCR), has becoming a potent target for various autoimmune diseases. Herein, we designed and synthesized imidazolidine-2,4-dione and 2-thioxothiazolidin-4-one derivatives as new LYP inhibitors. Among them, the cinnamic acids-based inhibitors (9p and 9r) displayed good LYP inhibitory activities (IC50 = 2.85–6.95 μM). Especially, the most potent inhibitor 9r was identified as competitive inhibitor (Ki = 1.09 μM) and bind LYP reversibly. Meanwhile, 9r exhibited better selectivity over other phosphatases than known LYP inhibitor A15. Furthermore, compound 9r could regulate TCR associated signaling pathway in Jurkat T cell.