49545-38-2

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 17823-27-7 2-(phenylimino)thiazolidin-4-one 
• 103-85-5 monophenylthiourea 
• 17823-27-7 2-phenylaminothiazol-4-one 
• 103-72-0 phenyl isothiocyanate 
• 109346-00-1 3-(4-methoxyphenyl)propiolamide 

Downstream Products

• 847021-38-9 7-(4-methoxy-phenyl)-2-phenylimino-2,3-dihydro-thiazolo[4,5-d]pyrimidin-5-ol 
• 847021-29-8 2-(4-{5-[1-(4-Methoxy-phenyl)-meth-(Z)-ylidene]-4-oxo-2-[(E)-phenylimino]-thiazolidin-3-yl}-butoxy)-isoindole-1,3-dione 
• 847021-20-9 2-(3-{5-[1-(4-Methoxy-phenyl)-meth-(Z)-ylidene]-4-oxo-2-[(E)-phenylimino]-thiazolidin-3-yl}-propoxy)-isoindole-1,3-dione 
• 847021-11-8 2-(2-{5-[1-(4-Methoxy-phenyl)-meth-(Z)-ylidene]-4-oxo-2-[(E)-phenylimino]-thiazolidin-3-yl}-ethoxy)-isoindole-1,3-dione 
• 96372-95-1 2-anilino-5-(4-methoxy-benzhydryl)-2-phenyl-thiazolidin-4-one 

Relevant academic research and scientific papers

Synthesis of thiazolone derivatives as novel soybean 15-LOX inhibitors

Background: Thiazole derivatives are known as important sulfur containing heterocycles which are present in a wide range of biologically active natural products. Methods: A series of thiazolone derivatives were synthesized and evaluated for their soybean 15-LOX inhibitory activity. The title compounds were prepared by the reaction of 2-arylthiazol-4(5H)-ones and different aromatic aldehydes. All compounds were characterized and evaluated against soybean 15-LOX. Results: Among the synthesized thiazolone derivatives, 5-(4-methoxybenzylidene)-2-((2-methoxyphenyl) amino)thiazol-4(5H)-one (3l) was found to be the most active compound comparing with quercetin as the reference drug. Conclusion: It seems that prepared thiazolones having methoxy groups both on aryl and aminoaryl moieties can be considered for further drug discovery research.

Synthesis and biological evaluation of 7-N-(n-alkoxyphthalimido)-2hydroxy- 4-aryl-6-aryliminothiazolidino [2,3-b] pyrimidines and related compounds

Substituted aryl thioureas 1a-c react with chloroacetic acid in the presence of anhydrous sodium acetate to furnish 2-aryliminothiazolidin-4-ones 2a-c. Condensation of ω-bromoalkoxyphthalimides 3a-c with 2a-c give the corresponding alkoxyphthalimide derivatives of 2-aryliminothiazolidin-4-ones 4a-i. These on condensation with araldehydes 5a-c yield 3-N-(alkoxyphthalimido)- 5-arylidene-2-aryliminothiazolidin-4-ones 7a-a′. In an alternative route 5a-c react with 2a-c to give 6a-i, which could be cyclised with urea in the presence of sodium acetate to yield the corresponding thiazolidinopyrimidine 8a-i. 7a-a′ are also prepared from 6a-i with 3a-c, which give final compound 9a-a′ on cyclisation. Alternatively, 8a-i when condensed with 3a-c also furnish the compounds 9a-a′. Evaluation of antimalarial and antibacterial activity is also reported.

A NEW APPROACH TO 5-ARYLIDENETHIAZOLIDIN-4-ONES

Reaction of 3-phenylpropynamides with heterocumulenes in the presence of a base yields 5-arylidenethiazolidin-4-ones by intramolecular nucleophilic addition to the α-carbon of the CC triple bond.