49546-71-6Relevant articles and documents
Ultrasound-assisted and trisodium citrate dihydrate-catalyzed green protocol for efficient and one-pot synthesis of substituted chromeno[3′,4′:5,6]pyrano[2,3-d]pyrimidines at ambient conditions
Brahmachari, Goutam,Nurjamal, Khondekar
, p. 1904 - 1908 (2019)
A simple, straightforward, and highly efficient multicomponent one-pot synthesis of a series of pharmaceutically interesting functionalized chromeno[3′,4′:5,6]pyrano[2,3-d]pyrimidines has been developed based on a low-cost and environmentally benign trisodium citrate dihydrate catalyst via ultrasound-assisted tandem reactions of 4-hydroxycoumarin, aromatic aldehydes, and barbituric acid/thiobarbituric acid in aqueous ethanol at ambient conditions. Metal-free synthesis, high atom-economy, good to excellent yields, short reaction time, operational simplicity, eco-friendliness, and mild reaction conditions are some of the important features of his protocol.
Knoevenagel condensation in aqueous media promoted by 2,2′-bipyridinium dihydrogen phosphate as a green efficient catalyst
Darvishzad, Shila,Daneshvar, Nader,Shirini, Farhad,Tajik, Hassan
, p. 2973 - 2984 (2021/04/19)
A 2,2′-Bipyridine-based ionic compound named 2,2′-bipyridinium dihydrogen phosphate was synthesized by addition of phosphoric acid to a solution of 2,2′-Bipyridine in dichloromethane. After the characterization using FT-IR, mass, 1H, 13C and 31P NMR techniques, it was used as a Bronsted dicationic acidic catalyst for the promotion of the synthesis of 2-arylidene malononitrile and 5-arylidene barbituric acid derivatives via Knoevenagel condensation reaction in water. Some of the advantages of this method are the utilization of an easy preparable, cost-effective and eco-friendly organic salt as a catalyst within high rates and yields of the reactions, simple and quick work-up and acceptable reusability of the catalyst.
BARBITURIC ACID DERIVATIVES AS SELF-TANNING SUBSTANCES
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Paragraph 0226; 0228-0229, (2020/02/20)
The present invention relates to the use of barbituric acid derivatives of the formula I as self-tanning substance, for increasing melanin synthesis, for improving melanin transport and/or improving the distribution of melanin in superbasal layers, to preparations comprising these barbituric acid derivatives, and to specific barbituric acid derivatives.