49565-62-0

Usage

Derivative of benzoic acid

2-(methylamino)-4-nitrobenzoic acid is derived from benzoic acid, which means it is a modified version of the parent compound benzoic acid.

Methylamino group

2-(methylamino)-4-nitrobenzoic acid contains a methylamino group (-NHCH3) attached to the benzene ring, which contributes to its chemical properties and reactivity.

Nitro group

The presence of a nitro group (-NO2) on the benzene ring makes 2-(methylamino)-4-nitrobenzoic acid more reactive and contributes to its potential applications in the synthesis of various drugs and organic compounds.

Use in pharmaceutical and chemical industries

2-(methylamino)-4-nitrobenzoic acid is commonly used as an intermediate in the synthesis of various drugs and organic compounds, making it an important compound in these industries.

Reagent in organic chemistry

2-(methylamino)-4-nitrobenzoic acid is also used as a reagent for the production of other compounds, showcasing its versatility in chemical reactions.

Potential applications in drug and material development

Due to its unique chemical properties and structure, 2-(methylamino)-4-nitrobenzoic acid has potential applications in the development of new drugs and materials.

Health and environmental hazards

It is important to handle 2-(methylamino)-4-nitrobenzoic acid with care, as it may pose potential health and environmental hazards if not properly managed.

Upstream product

• 858236-87-0 1-methyl-7-nitro-1H-quinazolin-4-one 
• 3558-13-2 4-nitro-2-methylaminobenzoic acid methyl ester 
• 19815-17-9 4-chloro-7-nitroquinazoline 
• 19815-14-6 7-nitroquinazolin-4-amine 
• 20872-93-9 7-nitroquinazolin-4(3H)-one 
• 858235-24-2 N-(7-nitro-quinazolin-4-yl)-acetamide 
• 857759-32-1 7-nitro-4-phenoxy-quinazoline 
• 730970-95-3 2-[methyl-(toluene-4-sulfonyl)-amino]-4-nitro-benzoic acid methyl ester 
• 16426-64-5 2-bromo-4-nitrobenzoic acid 
• 593-51-1 methylamine hydrochloride 
• 619-17-0 4-Nitroanthranilic acid 
• 99-55-8 2-methyl-5-nitroaniline 
• 951-97-3 2-acetamido-4-nitrobenzoic acid 
• 2879-79-0 N-(2-methyl-5-nitrophenyl)acetamide 

Relevant academic research and scientific papers

TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE

This disclosure relates to bivalent compounds (e.g., bi-functional small molecule compounds), compositions comprising one or more of the bivalent compounds, and to methods of use the bivalent compounds for the treatment of certain disease in a subject in need thereof. The disclosure also relates to methods for identifying such bivalent compounds.

Synthesis and antimicrobial activity of novel 4-Hydroxy-2-quinolone analogs

Alkyl quinolone has been proven to be a privileged scaffold in the antimicrobial drug discovery pipeline. In this study, a series of new 4-hydroxy-2-quinolinone analogs containing a long alkyl side chain at C-3 and a broad range of substituents on the C-6 and C-7 positions were synthesized. The antibacterial and antifungal activities of these analogs against Staphylococcus aureus, Escherichia coli, and Aspergillus flavus were investigated. The structure-activity relationship study revealed that the length of the alkyl chain, as well as the type of substituent, has a dramatic impact on the antimicrobial activities. Particularly, the brominated analogs 3j with a nonyl side chain exhibited exceptional antifungal activities against A. flavus (half maximal inhibitory concentration (IC50) = 1.05 μg/mL), which surpassed that of the amphotericin B used as a positive control. The antibacterial activity against S. aureus, although not as potent, showed a similar trend to the antifungal activity. The data suggest that the 4-hydroxy-2-quinolone is a promising framework for the further development of new antimicrobial agents, especially for antifungal treatment.

CRBN LIGANDS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.

Functionalization of quinazolin-4-ones part 1: Synthesis of novel 7-substituted-2-thioxo quinazolin-4-ones from 4-substituted-2-aminobenzoic acids and PPh3(SCN)2

4-(Nitro, amino, acetylamino)-2-aminobenzoic acid were allowed to react with PPh3(SCN)2 and gave the crossholding 7-nitro, 7-acetylamino- and 7-amino-2-thioxo quinazolin-4-ones respectively. The nature of the substituent at position 4 of the 2-aminobenzoic acids has significant influence on the outcome of the cyclisation reaction with PPh 3(SCN)2. Similarly, the nature of the substituent at position 7 of the 2-substituted quinazolin-4-ones significantly affected the ease with which alkylation reactions could be performed. The alkylation selectivity of the 7- substiuted-2-thioxo quinazolin-4-ones was found to depend on the nature of the alkyl halide and the nature of the substituent at position 2.

Efficient copper-catalyzed synthesis of N-alkylanthranilic acids via an ortho-substituent effect of the carboxyl group of 2-halobenzoic acids at room temperature

We have developed an efficient copper-catalyzed method for the synthesis of N-alkylanthranilic acids. The protocol uses inexpensive copper(I) iodide/racemic 1,1'-binaphthyl-2,2'-diol (rac-BINOL) as the catalyst/ligand system, readily available 2-halobenzoic acids and aliphatic amines as the starting materials, the coupling reactions were performed at room temperature, and various functionalities in the substrates were tolerated.