49571-47-3Relevant academic research and scientific papers
A stereoselective thiocyanate conjugate addition to electron deficient alkynes and concomitant cyclization to N,S-heterocycles
Dwivedi, Vikas,Rajesh, Manda,Kumar, Ravi,Kant, Ruchir,Sridhar Reddy, Maddi
, p. 11060 - 11063 (2017)
A regio- and stereoselective thiocyanate addition to ynones is achieved using KSCN in AcOH at 70 °C. The reaction is extendable to ynals, ynesulfones, ynoic acids and ynoates. Adducts from ynones were readily transformed into thiazine-2-thione derivatives under slightly modified reaction conditions. In contrast, thiocyanated adducts from ynamides underwent an in situ decyanative amido cyclization towards isothiazolones. None of these events needed any transition metal or catalyst, attaining a high synthetic value.
Synthesis of 2-Nitrothiophenes via Tandem Henry Reaction and Nucleophilic Substitution on Sulfur from β-Thiocyanatopropenals
Rong, Lin,Shen, Yingxia,Xiong, Guoxi,Gong, Yuefa
, p. 670 - 675 (2019/01/08)
A new synthetic route of 2-nitrothiophenes was described through a tetra-n-butylammonium fluoride-promoted or diisopropylethylamine-promoted tandem Henry reaction and nucleophilic substitution of nitromethane with 3-thiocyanatopropenals, which were conveniently prepared by the replacement reaction of 3-chloropropenals with potassium thiocyanate under a mild acidic condition.
