49594-70-9Relevant academic research and scientific papers
Light-responsive nanogated ensemble based on polymer grafted mesoporous silica hybrid nanoparticles
Lai, Jinping,Mu, Xue,Xu, Yunyan,Wu, Xiaoli,Wu, Chuanliu,Li, Chong,Chen, Jianbin,Zhao, Yibing
, p. 7370 - 7372 (2010)
Mesoporous silica nanoparticles grafted with light-responsive polymer on the outer surface were developed as novel nanogated ensembles, which allow encapsulation and release of drug and biological molecules under light irradiation.
Photocleavable and tunable thermoresponsive amphiphilic random copolymer: Self-assembly into micelles, dye encapsulation, and triggered release
Jana, Somdeb,Bose, Avijit,Saha, Anupam,Mandal, Tarun K.
, p. 1714 - 1729 (2017)
A double-responsive amphiphilic random copolymer (P(OEtOxA)-ran-PNBA) composed of thermoresponsive poly(oligo(2-ethyl-2-oxazoline)acrylate) (P(OEtOxA)) segments and photocleavable poly(2-nitrobenzyl acrylate) (PNBA) segments is synthesized via combination of cationic ring-opening polymerization (CROP) and reversible addition-fragmentation chain transfer (RAFT) polymerization techniques. The P(OEtOxA)-ran-PNBA copolymer exhibits lower critical solution (LCST)-type soluble-to-turbid phase transition in water with tunable cloud point (Tcp) with respect to chain length of P(OEtOxA) segment present. The photocleavage of PNBA segments by UV irradiation transforms amphiphilic P(OEtOxA)-ran-PNBA to fully hydrophilic P(OEtOxA)-ran-poly(acrylic acid) resulting in the appreciable increase of Tcp of copolymer in aqueous solution. Owing to the amphiphilic nature, the P(OEtOxA)-ran-PNBA copolymer molecules self-assemble into well-dispersed spherical micelles in water. There is a disruption of the copolymer micelles with UV light irradiation as well as shrinkage of micellar size with increasing temperature above the LCST of copolymer in solution. Finally, the encapsulation of hydrophobic guest molecule (nile red) into P(OEtOxA)-ran-PNBA copolymer micelles and thermo- and photo-triggered release of nile red are demonstrated.
Environment-friendly photolithography using poly(N-isopropylacrylamide)- based thermoresponsive photoresists
Ionov, Leonid,Diez, Stefan
, p. 13315 - 13319 (2009)
We report a novel approach for the temperature-triggered development of water-soluble photoresists based on photocleavable poly(N-isopropylacrylamide) copolymers. These copolymers are soluble in an aqueous environment below their Lower Critical Solution T
Self-Assembled Aptamer-Grafted Hyperbranched Polymer Nanocarrier for Targeted and Photoresponsive Drug Delivery
Yang, Lu,Sun, Hao,Liu, Yuan,Hou, Weijia,Yang, Yu,Cai, Ren,Cui, Cheng,Zhang, Penghui,Pan, Xiaoshu,Li, Xiaowei,Li, Long,Sumerlin, Brent S.,Tan, Weihong
, p. 17048 - 17052 (2018)
Photoresponsive materials are emerging as ideal carriers for precisely controlled drug delivery owing to their high spatiotemporal selectivity. However, drawbacks such as slow release kinetics, inherent toxicity, and lack of targeting ability hinder their translation into clinical use. We constructed a new DNA aptamer-grafted photoresponsive hyperbranched polymer, which can self-assemble into nanoparticles, thereby achieving biocompatibility and target specificity, as well as light-controllable release behavior. Upon UV-irradiation, rapid release induced by disassembly was observed for Nile Red-loaded nanoparticles. Further in vitro cell studies confirmed this delivery system's specific binding and internalization performance arising from the DNA aptamer corona. The DOX-loaded nanoassembly exhibited selective phototriggered cytotoxicity towards cancer cells, indicating its promising therapeutic effect as a smart drug delivery system.
Synthesis and controlled self-assembly of UV-responsive gold nanoparticles in block copolymer templates
Song, Dong-Po,Wang, Xinyu,Lin, Ying,Watkins, James J.
, p. 12788 - 12795 (2014)
We demonstrate the facile synthesis of gold nanoparticles (GNPs) functionalized by UV-responsive block copolymer ligands, poly(styrene)-b-poly(o-nitrobenzene acrylate)-SH (PS-b-PNBA-SH), followed by their targeted distribution within a lamellae-forming poly(styrene)-b-poly(2-vinylpyridine) (PS-b-P2VP) block copolymer. The multilayer, micelle-like structure of the GNPs consists of a gold core, an inner PNBA layer, and an outer PS layer. The UV-sensitive PNBA segment can be deprotected into a layer containing poly(acrylic acid) (PAA) when exposed to UV light at 365 nm, which enables the simple and precise tuning of GNP surface properties from hydrophobic to amphiphilic. The GNPs bearing ligands of different chemical compositions were successfully and selectively incorporated into the PS-b-P2VP block copolymer, and UV light showed a profound influence on the spatial distributions of GNPs. Prior to UV exposure, GNPs partition along the interfaces of PS and P2VP domains, while the UV-treated GNPs are incorporated into P2VP domains as a result of hydrogen bond interactions between PAA on the gold surface and P2VP domains. This provides an easy way of controlling the arrangement of nanoparticles in polymer matrices by tailoring the nanoparticle surface using UV light. (Figure Presented).
Mitochondria-Targeted delivery and light controlled release of iron prodrug and CO to enhance cancer therapy by ferroptosis
Gao, Fan,Gao, Fan,Zhang, Wen-Jian,Hong, Chun-Yan,You, Ye-Zi,Nie, Xuan,Zhang, Ze,Chen, Guang,Xia, Lei,Wang, Long-Hai,Zhang, Wen-Jian,Hong, Chun-Yan,You, Ye-Zi,Wang, Fei,Wang, Chang-Hui,Hao, Zong-Yao
supporting information, p. 3478 - 3486 (2020/03/06)
Mitochondrial malfunction is considered to be a decisive signal of apoptosis. It would be a promising strategy to target mitochondria in cancer cells to generate reactive oxygen species (ROS), thus directly inducing mitochondrial damage. We herein reported a mitochondria-Targeted, photo-responsive polymer (Mito-PNBE), which can self-Assemble into nanoparticles (Fe-CO@Mito-PNBE) encapsulated with diphenylcyclopropenone (light-responsive CO prodrugs) and aminoferrocene-based prodrugs via hydrophobic interactions. Upon UV-irradiation, the rapid release of CO and aminoferrocene-based prodrugs caused by disassembly was observed. On one hand, the released carbon monoxide in mitochondria could enhance ROS generation and accelerate oxidative metabolism. On the other hand, the aminoferrocene-based prodrugs will release Fe3+/Fe2+ ions in the tumor microenvironment, thus triggering the Fenton reaction, which generates more ROS and damages the mitochondria. Thus, the synergistic effect of the two drugs produces enough amounts of ROS in the mitochondria, leading to mitochondrial collapse with an enhanced cancer therapeutic effect. This multifunctional platform has potential in precision cancer therapy.
