49609-03-2

Basic information

• Product Name: 2-Chloro-7-nitroquinoline
• Synonyms: 2-Chloro-7-nitroquinoline
• CAS NO: 49609-03-2
• Molecular Formula: C₉H₅ClN₂O₂
• Molecular Weight: 208.6012
• Mol File: 49609-03-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 137-139 °C(Solv: ethanol (64-17-5))
• Boiling Point: 363.4±22.0 °C(Predicted)
• Appearance: /
• Density: 1.484±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -3.35±0.50(Predicted)
• CAS DataBase Reference: 2-Chloro-7-nitroquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-7-nitroquinoline(49609-03-2)
• EPA Substance Registry System: 2-Chloro-7-nitroquinoline(49609-03-2)

Safety Data

• Hazardous Substances Data: 49609-03-2(Hazardous Substances Data)

Usage

General Description

2-chloro-7-nitroquinoline is a chemical compound with the molecular formula C9H5ClN2O2. It is a yellow solid that is used as an intermediate in the synthesis of pharmaceuticals and agricultural chemicals. 2-chloro-7-nitroquinoline is a nitroquinoline derivative, which makes it useful in medicinal chemistry for its potential biological activity. 2-chloro-7-nitroquinoline is also used in research and development as a building block for the synthesis of various heterocyclic compounds. This chemical has potential applications in drug discovery and development due to its unique structural features, making it a valuable tool in the field of organic chemistry.

Upstream product

• 14753-17-4 7-Nitro-chinolin-1-oxyd 
• 612-62-4 2-Chloroquinoline 
• 99-09-2 3-nitro-aniline 
• 613-51-4 7-nitroquinoline 
• 75755-37-2 7-nitrocarbostyril 

Downstream Products

• 1354222-16-4 2-methoxyquinolin-7-amine 
• 1354222-15-3 2-methoxy-7-nitroquinoline 
• 49609-04-3 2-amino-7-nitroquinoline 
• 75755-31-6 7-nitro-2-quinoline 
• 75755-33-8 7-nitro-2-quinoline 

Relevant articles and documents

Trk inhibitor, preparation method and applications thereof

The invention belongs to the field of medicine, and particularly relates to a Trk inhibitor, a preparation method and applications thereof, mainly to compounds represented by a formula A1, a formula A2, a formula A3 or a formula A4, pharmaceutically accep

NUCLEOPHILIC HETEROAROMATIC SUBSTITUTIONS. XXXIX. THE REACTION OF α- AND γ-- AND α- AND γ--7-NITROQUINOLINE WITH PIPERIDINE IN BENZONITRILE: BASE CATALYSIS AND O vs S REACTIVITY

The reactivity of the title compounds with piperidine has been examined.Product analysis showed that substitution is accompanied by other processes, the extent of which depends on the reactivity of the substrates towards nucleophilic substitution and is greatest in the case of the γ-arylthio derivative, which does not undergo substitution at all.Accordingly, a kinetic analysis of the reaction could be performed only for the two aryloxy and the α-arylthio derivatives.Second-order rate coefficients for the reactions of the α-substituted quinolines were found to be independent of amine concentration and the α-aryloxy derivative was found to be only ca 4 times as reactive as the α-arylthio compound.In contrast, the reaction of the γ-aryloxy derivative followed third-order kinetics and turned out to be base-catalysed because it was accelerated by added quinuclidine.The reaction mechanisms are discussed in the light of these observations and other, previously reported, facts.