49609-03-2

Usage

Uses

Used in Pharmaceutical Industry:
2-chloro-7-nitroquinoline is used as a chemical intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs with potential therapeutic applications.
Used in Agricultural Chemical Industry:
2-chloro-7-nitroquinoline is utilized as a building block in the synthesis of agricultural chemicals, aiding in the creation of novel compounds with potential use in crop protection and pest control.
Used in Research and Development:
2-chloro-7-nitroquinoline is employed as a research compound in the development of heterocyclic compounds, providing a foundation for the synthesis of complex organic molecules with diverse applications in various fields.
Used in Drug Discovery and Development:
Due to its unique structural features, 2-chloro-7-nitroquinoline is used as a valuable tool in drug discovery and development, offering potential applications in the creation of new therapeutic agents with improved efficacy and selectivity.

Upstream product

• 75755-37-2 7-nitrocarbostyril 
• 14753-17-4 7-Nitro-chinolin-1-oxyd 
• 99-09-2 3-nitro-aniline 
• 612-62-4 2-Chloroquinoline 
• 613-51-4 7-nitroquinoline 

Downstream Products

• 75755-33-8 7-nitro-2-quinoline 
• 75755-31-6 7-nitro-2-quinoline 
• 49609-04-3 2-amino-7-nitroquinoline 
• 1354222-15-3 2-methoxy-7-nitroquinoline 
• 1354222-16-4 2-methoxyquinolin-7-amine 

Relevant academic research and scientific papers

Trk inhibitor, preparation method and applications thereof

The invention belongs to the field of medicine, and particularly relates to a Trk inhibitor, a preparation method and applications thereof, mainly to compounds represented by a formula A1, a formula A2, a formula A3 or a formula A4, pharmaceutically accep

7-Aminoquinolines. A novel class of agents active against herpesviruses

A series of 7-aminoquinoline derivatives was synthesized and evaluated for their capacity to produce cytotoxicity in KB cells and to inhibit the replication of herpes simplex virus (HSV) type 1. All compounds tested inhibited the replication of HSV-1 with 50% inhibitory concentrations in the range of 2-50 μg/mL. The antiviral activity of many compounds, however, was separated from cytotoxicity to replicating uninfected cells by only two- to fivefold higher than those required for antiviral activity. Nonetheless, six compounds (10, 28, 29, 32, 34, and 36) were identified in which the separation was greater than fivefold. All compounds examined were more potent inhibitors of viral DNA synthesis than the cellular DNA synthesis.

NUCLEOPHILIC HETEROAROMATIC SUBSTITUTIONS. XXXIX. THE REACTION OF α- AND γ-- AND α- AND γ--7-NITROQUINOLINE WITH PIPERIDINE IN BENZONITRILE: BASE CATALYSIS AND O vs S REACTIVITY

The reactivity of the title compounds with piperidine has been examined.Product analysis showed that substitution is accompanied by other processes, the extent of which depends on the reactivity of the substrates towards nucleophilic substitution and is greatest in the case of the γ-arylthio derivative, which does not undergo substitution at all.Accordingly, a kinetic analysis of the reaction could be performed only for the two aryloxy and the α-arylthio derivatives.Second-order rate coefficients for the reactions of the α-substituted quinolines were found to be independent of amine concentration and the α-aryloxy derivative was found to be only ca 4 times as reactive as the α-arylthio compound.In contrast, the reaction of the γ-aryloxy derivative followed third-order kinetics and turned out to be base-catalysed because it was accelerated by added quinuclidine.The reaction mechanisms are discussed in the light of these observations and other, previously reported, facts.