49615-91-0

Usage

Chemical class

2-(2-oxopropoxy)benzonitrile belongs to the class of benzonitrile compounds.

Molecular weight

The molecular weight of 2-(2-oxopropoxy)benzonitrile is 191.19 g/mol.

Uses

2-(2-oxopropoxy)benzonitrile is used in various chemical and pharmaceutical processes, including as an intermediate in the synthesis of pharmaceutical drugs and in the production of agrochemicals.

Main use

The main use of 2-(2-oxopropoxy)benzonitrile is as a building block in organic synthesis.

Chemical reactivity

2-(2-oxopropoxy)benzonitrile is known to undergo various chemical reactions and has potential applications in the field of medicinal chemistry and drug development.

Upstream product

• 611-20-1 salicylonitrile 
• 78-95-5 chloroacetone 
• 598-31-2 1-bromoacetone 

Downstream Products

• 78993-50-7 2-Acetyl-3-phenylacetamidobenzofuran 
• 803684-81-3 (E)-N-(2-acetyl-5-{2-[2-(3,4-dimethoxyphenyl)ethylcarbamoyl]-1-methylvinyl}benzofuran-3-yl)-5-methylisoxazole-4-carboxamide 
• 688757-01-9 (E)-N-{2-acetyl-5-[1-methyl-3-oxo-3-(4-phenylpiperazin-1-yl)-1-propenyl]benzofuran-3-yl}-5-methylisoxazole-4-carboxamide 
• 803684-35-7 (E)-3-(2-acetyl-3-aminobenzofuran-5-yl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-2-butenamide 
• 688757-95-1 (E)-3-(2-acetyl-3-aminobenzofuran-5-yl)-1-(4-phenylpiperazin-1-yl)-2-buten-1-one 
• 688757-75-7 2-acetyl-5-bromo-3-(3-phenylprop-2-enonyl)aminobenzo[b]furan 
• 636992-53-5 1-(3-amino-5-bromo-benzofuran-2-yl)-ethanone 
• 295346-39-3 5-bromo-2-(2-oxopropoxy)benzonitrile 
• 49615-96-5 1-(3-aminobenzofuran-2-yl)ethan-1-one 

Relevant academic research and scientific papers

Xanthine derivatives, their preparation and use

The present invention relates to a xanthine derivative, a pharmaceutically acceptable salt thereof, a solvate of the derivative, a solvate of the pharmaceutically acceptable salt, a chemically protected form or prodrug thereof and a preparation method and a use thereof; and also relates to an intermediate compound used for preparing the xanthine derivative and a preparation method of the intermediate compound. The xanthine derivative and a pharmaceutical composition thereof effectively inhibit the activity of DPP-IV, and can be used for preparing a drug for diseases associated with dipeptidyl peptidase (DPP-IV).

Syntheses of 3-acetoacetylaminobenzo[b]furan derivatives having cysteinyl leukotriene 2 receptor antagonistic activity

Novel 3-acetoacetylaminobenzo[b]furan derivatives having a modified triene system at the 3-position were synthesized starting with 3-aminobenzo[b]furans. The enol isomers, 3-[(3-hydroxybul-2-enonyl)amino]benzo[b]furans (1), of the 3-acetoacetylaminobenzo[b]furans were obtained as stable isomers owing to formation of a hydrogen bonding between the enol hydroxyl group and the amidocarbonyl group. The planarity of the C-2 substituent through the C-3 side chain suggested the existence of a modified conjugational triene system in the enol compound. Cysteinyl leukotriene 1 and 2 receptor antagonistic activities for these compounds were evaluated. 2-(4-Cyanobenzoyl or ethoxycarbonyl)-3-[(2-cyano-3-hydroxybut-2-enonyl)amino]benzo[e]furans (15g, 15o, 15u) were moderately active.

Synthetic Studies in Benzofurans : Part XI - Synthesis of Some Benzofuropyridine Derivatives

Synthesis of 2-acyl-3-aminobenzofurans from salicylonitrile and α-haloketones and their conversion into new tricyclic heterocycle benzofuropyridine derivatives through Friedlanders method are described.Some other routes for the synthesis of various