4964-69-6

Basic information

• Product Name: 5-Chloroquinaldine
• Synonyms: 2-Methyl-5-chloroquinoline;5-CHLORO-2-METHYL-QUINOLINE;5-CHLOROQUINALDINE;5-CHLOROQUINALDINE TRIHYDRATE;2-methyl-5-chloroquinline
• CAS NO: 4964-69-6
• Molecular Formula: C₁₀H₈ClN
• Molecular Weight: 231.68
• EINECS: -0
• Mol File: 4964-69-6.mol
• Article Data: 8

Chemical Properties

• Melting Point: 52-54°C
• Boiling Point: 278.177°C at 760 mmHg
• Flash Point: 148.736°C
• Appearance: /
• Density: 1.225g/cm³
• Vapor Pressure: 0.007mmHg at 25°C
• Refractive Index: 1.635
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.73±0.50(Predicted)
• CAS DataBase Reference: 5-Chloroquinaldine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloroquinaldine(4964-69-6)
• EPA Substance Registry System: 5-Chloroquinaldine(4964-69-6)

Safety Data

• Hazardous Substances Data: 4964-69-6(Hazardous Substances Data)

Usage

General Description

5-Chloroquinaldine is an organic chemical compound with the molecular formula C10H8ClN. It is a yellow solid substance that is soluble in organic solvents and exhibits a strong odor. 5-Chloroquinaldine is primarily used as an intermediate in the production of various agrochemicals and pharmaceuticals. It is commonly used as a building block in the synthesis of pesticides, herbicides, and other crop protection products. Additionally, it is utilized in the manufacturing of pharmaceuticals and research chemicals. 5-Chloroquinaldine is considered to be a hazardous substance and should be handled with caution due to its potential health and environmental risks.

InChI:InChI=1/C10H8ClN/c1-7-5-6-8-9(11)3-2-4-10(8)12-7/h2-6H,1H3

Upstream product

• 50-00-0 formaldehyd 
• 108-42-9 3-chloro-aniline 
• 123-73-9 trans-Crotonaldehyde 
• 64-17-5 ethanol 
• 18826-95-4 1.3-butanediol 
• 107-21-1 ethylene glycol 
• 4784-77-4 (E)-1-Bromo-2-butene 
• 15426-14-9 3,3'-dichloroazobenzene 
• 106237-28-9 β-(m-chloroanilino)crotonaldehyde 
• 75-07-0 acetaldehyde 

Downstream Products

• 1027374-02-2 Acetic acid 3-[(E)-2-(5-chloro-quinolin-2-yl)-vinyl]-phenyl ester 
• 1365920-50-8 C₂₃H₂₀N₂S 
• 511231-70-2 5-chloro-quinoline-2-carboxylic acid 
• 63010-74-2 4,5-dichloro-2-methyl-quinoline 
• 143840-93-1 sodium {3-[2-(5-chloro-2-quinolinyl)-(E)-ethenyl]phenoxy}butanoate 
• 108165-12-4 4-{3-[(E)-2-(5-Chloro-quinolin-2-yl)-vinyl]-phenoxy}-butyric acid ethyl ester 
• 1027848-32-3 3-[(E)-2-(5-Chloro-quinolin-2-yl)-vinyl]-phenol 

Relevant articles and documents

Quinolines synthesis by reacting 1,3-butanediol with anilines in the presence of iron catalysts

2-, 4-, 6-, 7-, and 8-substituted quinolines were synthesized in 78–95% yield by the reaction of 1,3- butanediol with anilines in the presence of iron catalysts in carbon tetrachloride.

Copper-Promoted Tandem Reaction of Azobenzenes with Allyl Bromides via N=N Bond Cleavage for the Regioselective Synthesis of Quinolines

A copper-promoted tandem reaction of a variety of azobenzenes and allyl bromides via N=N bond cleavage to regioselectively construct quinoline derivatives has been developed. The azobenzenes act as not only construction units but also an oxidant for quinoline formation.

Improved synthesis of quinaldines by the Skraup reaction

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